Vtcn1 - V-set domain containing T cell activation inhibitor 1 Gene

Also Known as B7x; B7h4; B7s1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 242122

Summary

Enables signaling receptor binding activity. Acts upstream of or within positive regulation of interleukin-2 production; regulation of T cell activation; and response to protozoan. Located in external side of plasma membrane. Is expressed in hemolymphoid system gland; lung; male reproductive gland or organ; and pancreas. Orthologous to human VTCN1 (V-set domain containing T cell activation inhibitor 1). [provided by Alliance of Genome Resources, Apr 2022]

Vtcn1 Products (3)

mRNA Protein Name
NM_001409755.1 NP_001396684.1 V-set domain containing T-cell activation inhibitor 1 isoform 2
NM_001409758.1 NP_001396687.1 V-set domain containing T-cell activation inhibitor 1 isoform 2
NM_178594.4 NP_848709.2 V-set domain containing T-cell activation inhibitor 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables signaling receptor binding IDA
IDA: Inferred from direct assay
16751379 MGI
enables signaling receptor binding IGI
IGI: Inferred from genetic interaction
15585831 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within interleukin-4 production IMP
IMP: Inferred from mutant phenotype
16914726 MGI
acts upstream of or within negative regulation of T cell activation IDA
IDA: Inferred from direct assay
15585831 MGI
acts upstream of or within positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within positive regulation of interleukin-2 production IMP
IMP: Inferred from mutant phenotype
16751379 MGI
acts upstream of or within response to protozoan IMP
IMP: Inferred from mutant phenotype
16914726 MGI
acts upstream of or within type II interferon production IMP
IMP: Inferred from mutant phenotype
16914726 MGI
Cellular Component GO Annotation Evidence References Source
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17051145 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

V-set domain containing T-cell activation inhibitor 1

  • B7 homolog 4

  • immune costimulatory protein B7-H4

  • t cell costimulatory molecule B7x

Recombinant Vtcn1 Proteins

Cat. No. Product Name Accession Purity
HY-P7641 B7-H4 Protein, Mouse (HEK293, Fc) AAH32925.1(F29-P258) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74394 B7-H4 Protein, Mouse (HEK293, His) Q7TSP5 (F29-S256) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P990059 Puxitatug 99.00% Phase 3
HY-P990953 Zubotamig Inhibitor 96.46% Phase 2
HY-P990996 Felmetatug 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15721 VTCN1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17471 Vtcn1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23929 Vtcn1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991703 Mocertatug Inhibitor 98% Unkown
HY-P990918 Emiltatug 99% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Vtcn1 NCBI NCBI:79679