Fgfr4 - fibroblast growth factor receptor 4 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25114

About Fgfr4

Primary_assembly 17: 9,461,547-9,476,242 reverse strand.mRatBN7.2:CM026990.1

This gene has 3 transcripts (splice variants), 122 orthologues, 54 paralogues and is associated with 23 phenotypes. Biased expression in Lung (RPKM 84.6), Kidney (RPKM 61.7) and 4 other tissues.

Summary

Predicted to enable Fibroblast Growth Factor binding activity; fibroblast growth factor-activated receptor activity; and heparin binding activity. Acts upstream of or within Fibroblast Growth Factor receptor signaling pathway. Predicted to be located in several cellular components, including Golgi apparatus; endoplasmic reticulum; and transport vesicle. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Predicted to colocalize with cell-cell junction. Human ortholog(s) of this gene implicated in carcinoma (multiple); liver cirrhosis; prostate cancer; and stomach Cancer. Orthologous to human FGFR4 (Fibroblast Growth Factor receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Fgfr4 Products (1)

mRNA Protein Name
NM_001109904.1 NP_001103374.1 fibroblast growth factor receptor 4 precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within fibroblast growth factor receptor signaling pathway IPI
IPI: Inferred from physical interaction
10766846 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Fgfr4 Protein Structure

Ig_3

Ig_3: pfam13927 (33 - 100)

Ig

Ig: cd00096 (49 - 53)

Ig

Ig: cd00096 (80 - 84)

Ig

Ig: cd00096 (94 - 99)

Ig

Ig: cl11960 (142 - 236)

Ig

Ig: cd00096 (163 - 167)

Ig

Ig: cd00096 (176 - 180)

Ig

Ig: cd00096 (202 - 206)

Ig

Ig: cd00096 (216 - 221)

Ig

Ig: cd00096 (229 - 232)

Ig

Ig: cl11960 (244 - 346)

Ig

Ig: cd00096 (262 - 266)

Ig

Ig: cd00096 (275 - 279)

Ig

Ig: cd00096 (311 - 315)

Ig

Ig: cd00096 (325 - 330)

Ig

Ig: cd00096 (338 - 341)

PKc_like

PKc_like: cl21453 (452 - 765)

  • 0
  • 200
  • 400
  • 600
  • 801 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor receptor 4

  • FGFR-4

Recombinant Fgfr4 Proteins

Cat. No. Product Name Accession Purity
HY-P73061 FGFR-4 Protein, Rat (HEK293, Fc, Solution) Q498D6 (F17-D367) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P75190 FGFR-4 Protein, Rat (HEK293, His) Q498D6 (F17-D367) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-184598 CYB-5067 Degrader / Unkown
HY-184250 FGFR-IN-28 Inhibitor / Unkown
HY-181752 FGFR3-IN-12 Inhibitor / Unkown
HY-183780 FGFR-IN-27 Inhibitor / Unkown
HY-183909 EphB1-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fgfr4 NCBI NCBI:2264