Aqp1 - aquaporin 1 Gene

Also Known as CHIP28

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25240

Summary

Enables glycerol transmembrane transporter activity and water channel activity. Involved in several processes, including glycerol transport; lateral ventricle development; and positive regulation of lamellipodium assembly. Located in several cellular components, including basolateral plasma membrane; brush border; and neuronal cell body membrane. Biomarker of artery disease (multiple); autosomal recessive polycystic kidney disease; brain disease (multiple); diabetes mellitus; and uveitis. Orthologous to human AQP1 (Aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Aqp1 Products (1)

mRNA Protein Name
NM_012778.2 NP_036910.1 aquaporin-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables glycerol transmembrane transporter activity IDA
IDA: Inferred from direct assay
7491270 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16354160 RGD
enables water channel activity IMP
IMP: Inferred from mutant phenotype
11804854 RGD
Biological Process GO Annotation Evidence References Source
involved in glycerol transmembrane transport IDA
IDA: Inferred from direct assay
7491270 RGD
involved in hyperosmotic response IEP
IEP: Inferred from expression pattern
19776169 RGD
involved in lateral ventricle development IEP
IEP: Inferred from expression pattern
16133142 RGD
involved in metanephric proximal tubule development IEP
IEP: Inferred from expression pattern
30645697 RGD
involved in positive regulation of epithelial cell migration IMP
IMP: Inferred from mutant phenotype
19539607 RGD
involved in positive regulation of lamellipodium assembly IMP
IMP: Inferred from mutant phenotype
19539607 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
19351613 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
18248364 RGD
involved in water transport IMP
IMP: Inferred from mutant phenotype
11804854 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
16133142 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
17553469 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11804854 RGD
located in brush border IDA
IDA: Inferred from direct assay
16133142 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
16309835 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
7491270 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aquaporin-1

  • AQP-1

  • Aquaporin 1 (aquaporin channel forming integral protein 28 (CHIP))

  • aquaporin 1 (Colton blood group)

  • aquaporin-CHIP

  • water channel protein for red blood cells and kidney proximal tubule

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N6016 Bacopaside II 98.86% Unkown
HY-110200 TC AQP1 1 Inhibitor 98.03% Unkown
HY-N2013 Aristolactam I 99.44% Unkown
HY-174166 AqF026 Activator 99.05% Unkown
HY-N4246 Bacopaside I 99.20% Unkown
HY-RS00871 AQP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17735 Aqp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24200 Aqp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aqp1 NCBI NCBI:358