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AGO1 - argonaute RISC component 1 Gene

Also Known as Q99; EIF2C; hAgo1; EIF2C1; GERP95

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26523

About AGO1

Cytogenetic location: 1p34.3 Genomic coordinates (GRCh38): 1:35,869,761-35,930,532 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues, 3 paralogues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 4.5), brain (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to MicroRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon. [provided by RefSeq, Nov 2015]

AGO1 Products (3)

mRNA	Protein	Name
NM_001317122.2	NP_001304051.1	protein argonaute-1 isoform 1x
NM_001317123.2	NP_001304052.1	protein argonaute-1 isoform 2
NM_012199.5	NP_036331.1	protein argonaute-1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables RNA binding	IDA IDA: Inferred from direct assay	23809764	GOA
NOT enables RNA endonuclease activity	IDA IDA: Inferred from direct assay	23809764	GOA
enables RNA polymerase II complex binding	IDA IDA: Inferred from direct assay	25336585	GOA
enables core promoter sequence-specific DNA binding	IMP IMP: Inferred from mutant phenotype	25336585	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA
enables miRNA binding	IDA IDA: Inferred from direct assay	15260970	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12526743	GOA
enables single-stranded RNA binding	IDA IDA: Inferred from direct assay	19966796	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RISC complex assembly	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IDA IDA: Inferred from direct assay	19966796	GOA
involved in RNA secondary structure unwinding	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA processing	IMP IMP: Inferred from mutant phenotype	22795694	GOA
involved in miRNA-mediated gene silencing by inhibition of translation	IDA IDA: Inferred from direct assay	18771919	GOA
NOT involved in miRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA
involved in negative regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	23426184	GOA
involved in nuclear-transcribed mRNA catabolic process	IDA IDA: Inferred from direct assay	18771919	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	25336585	GOA
involved in pre-miRNA processing	IDA IDA: Inferred from direct assay	19966796	GOA
NOT involved in siRNA-mediated gene silencing by mRNA destabilization	IDA IDA: Inferred from direct assay	15260970	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of RISC complex	IDA IDA: Inferred from direct assay	15260970	GOA
part of RISC-loading complex	IDA IDA: Inferred from direct assay	19966796	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	15260970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AGO1 Protein Structure

ArgoL1

PAZ

Piwi

0
200
400
600
800
857 a.a.

Protein Preferred Names	Protein Names
protein argonaute-1	Golgi Endoplasmic Reticulum protein 95 kDa

AGO1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AGO1	Q9UL18	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	33961781
Intra	AGO1	Q9UL18	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	35271311
Intra	AGO1	Q9UL18	TNRC6A	Homo sapiens	Q8NDV7	Anti Tag CoIP	19716330
Intra	AGO1	Q9UL18	LIMD1	Homo sapiens	Q9UGP4	Pull Down	28683311
Intra	AGO1	Q9UL18	LIMD1	Homo sapiens	Q9UGP4	Anti Tag CoIP	28683311
Intra	AGO1	Q9UL18	LIMD1	Homo sapiens	Q9UGP4	Confocal	28683311
Intra	AGO1	Q9UL18	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	AGO1	Q9UL18	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	AGO1	Q9UL18	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	17932509
Intra	AGO1	Q9UL18	DICER1	Homo sapiens	Q9UPY3	CoIP	12526743
Intra	AGO1	Q9UL18	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	19716330
Intra	AGO1	Q9UL18	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	17932509
Intra	AGO1	Q9UL18	DICER1	Homo sapiens	Q9UPY3	Anti Tag CoIP	33961781
Intra	AGO1	Q9UL18	DICER1	Homo sapiens	Q9UPY3	Anti Bait CoIP	12526743
Intra	AGO1	Q9UL18	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	35271311
Intra	AGO1	Q9UL18	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	33961781
Intra	AGO1	Q9UL18	TNRC6C	Homo sapiens	Q9HCJ0	Confocal	19383768
Intra	AGO1	Q9UL18	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	35271311
Intra	AGO1	Q9UL18	TNRC6C	Homo sapiens	Q9HCJ0	Anti Tag CoIP	19383768
Intra	AGO1	Q9UL18	TNRC6B	Homo sapiens	Q9UPQ9-2	Confocal	19383768
Intra	AGO1	Q9UL18	TNRC6B	Homo sapiens	Q9UPQ9-2	Y2H	17891150
Intra	AGO1	Q9UL18	TNRC6B	Homo sapiens	Q9UPQ9-2	Pull Down	17891150
Intra	AGO1	Q9UL18	TNRC6B	Homo sapiens	Q9UPQ9-2	Anti Tag CoIP	19383768

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AGO1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74424	AGO1 Protein, Human (sf9, His)	Q9UL18 (M1-A857)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tremor	Medicament-Induced Tremor Medication-Induced Postural Tremor
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia
Cervical Non-Keratinizing Squamous Cell Carcinoma
Retinitis Pigmentosa 7	Leber Congenital Amaurosis 18 RP7 Retinitis Pigmentosa 7, Digenic Form Retinitis Pigmentosa 7 And Digenic Form Retinitis Pigmentosa 7, Digenic LCA18 Retinitis Pigmentosa 7 Digenic
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00452	AGO1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18906	Ago1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25397	Ago1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AGO1	RGD	RGD:1304619
Felis catus	AGO1	VGNC	VGNC:107483
Bos taurus	AGO1	VGNC	VGNC:25732
Macaca mulatta	AGO1	VGNC	VGNC:81346
Mus musculus	AGO1	MGD	MGI:2446630
Canis familiaris	AGO1	VGNC	VGNC:54192
Others	AGO1	NCBI