Wnk4 - WNK lysine deficient protein kinase 4 Gene

Also Known as Ac2-059; Prkwnk4

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 287715

Summary

Enables protein serine/threonine kinase activity. Involved in negative regulation of sodium ion transport and protein phosphorylation. Located in cytosol and membrane. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension and pseudohypoaldosteronism. Orthologous to human WNK4 (WNK lysine deficient protein kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Wnk4 Products (1)

mRNA Protein Name
NM_175579.3 NP_783169.2 serine/threonine-protein kinase WNK4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16083423 RGD
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
16083423 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of sodium ion transport IDA
IDA: Inferred from direct assay
16204408 RGD
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
16083423 RGD
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
25515571 RGD
located in membrane IDA
IDA: Inferred from direct assay
25515571 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein kinase WNK4

  • WNK4 Ser/Thr kinase

  • protein kinase lysine-deficient 4

  • protein kinase with no lysine 4

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100626 WNK463 Inhibitor 99.75% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Wnk4 NCBI NCBI:65266