Homer1 - homer scaffold protein 1 Gene

Also Known as Vesl-1; HOMER1F

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29546

Summary

Enables several functions, including identical protein binding activity; scaffold protein binding activity; and type 5 metabotropic glutamate receptor binding activity. A structural constituent of postsynapse. Involved in several processes, including G protein-coupled glutamate receptor signaling pathway; protein tetramerization; and regulation of dendritic spine maintenance. Located in dendritic shaft; dendritic spine; and neuronal cell body. Is active in glutamatergic synapse and postsynaptic density. Colocalizes with excitatory synapse. Orthologous to human HOMER1 (homer scaffold protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Homer1 Products (1)

mRNA Protein Name
NM_031707.2 NP_113895.1 homer protein homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables G protein-coupled glutamate receptor binding IPI
IPI: Inferred from physical interaction
15758184 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
19345194 RGD
enables molecular adaptor activity IPI
IPI: Inferred from physical interaction
10433269 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9069287 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
9727012 RGD
enables scaffold protein binding IPI
IPI: Inferred from physical interaction
10433269 RGD
enables signaling receptor binding IDA
IDA: Inferred from direct assay
9069287 RGD
enables structural constituent of postsynapse IDA
IDA: Inferred from direct assay
17880892 RGD
enables structural constituent of postsynapse IMP
IMP: Inferred from mutant phenotype
17880892 RGD
enables type 5 metabotropic glutamate receptor binding IPI
IPI: Inferred from physical interaction
16554037 RGD
Biological Process GO Annotation Evidence References Source
involved in G protein-coupled glutamate receptor signaling pathway IDA
IDA: Inferred from direct assay
9069287 RGD
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
15308308 RGD
involved in protein localization to synapse IDA
IDA: Inferred from direct assay
12867517 RGD
involved in protein tetramerization IDA
IDA: Inferred from direct assay
19345194 RGD
involved in regulation of dendritic spine maintenance IMP
IMP: Inferred from mutant phenotype
19345194 RGD
involved in regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
19345194 RGD
involved in response to cocaine IEP
IEP: Inferred from expression pattern
18932227 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
15813924 RGD
Cellular Component GO Annotation Evidence References Source
located in dendrite IDA
IDA: Inferred from direct assay
16554037 RGD
located in dendritic shaft IDA
IDA: Inferred from direct assay
9069287 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
30021165 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
9069287 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10433269 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
17880892 RGD
located in neuron spine IDA
IDA: Inferred from direct assay
19345194 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
9069287 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
10433269 RGD
located in postsynaptic density IDA
IDA: Inferred from direct assay
10433269 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

homer protein homolog 1

  • PSD-Zip45

  • VASP/Ena-related gene up-regulated during seizure and LTP 1

  • homer homolog 1

  • homer scaffolding protein 1

  • homer, neuronal immediate early gene, 1

  • scaffold protein

Homer1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
Homer1 Q9Z214 Grm5 Mus musculus Q3UVX5
NMR
23911326
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100001 SKF-96365 (hydrochloride) 99.93% Unkown
HY-125942 SKF-96365 99.97% Unkown
HY-RS06283 HOMER1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21139 Homer1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27657 Homer1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Homer1 NCBI NCBI:9456