Pecam1 - platelet and endothelial cell adhesion molecule 1 Gene

Also Known as CD31; Pecam

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29583

Summary

Enables protein Phosphatase binding activity. Involved in several processes, including cellular response to interferon-gamma; negative regulation of GTPase activity; and negative regulation of actin filament polymerization. Located in cell surface and ruffle. Used to study pulmonary hypertension. Biomarker of Bacterial pneumonia; orchitis; and osteoarthritis. Human ortholog(s) of this gene implicated in coronary artery disease (multiple); lung non-small cell carcinoma; neuroblastoma; and psoriatic arthritis. Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Pecam1 Products (1)

mRNA Protein Name
NM_031591.2 NP_113779.1 platelet endothelial cell adhesion molecule precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
9388260 RGD
Biological Process GO Annotation Evidence Références Source
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
21414398 RGD
involved in cellular response to transforming growth factor beta stimulus IEP
IEP: Inferred from expression pattern
18466611 RGD
involved in cellular response to type II interferon IEP
IEP: Inferred from expression pattern
18466611 RGD
involved in negative regulation of GTPase activity IDA
IDA: Inferred from direct assay
17662049 RGD
involved in negative regulation of actin filament polymerization IDA
IDA: Inferred from direct assay
17662049 RGD
involved in negative regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
17662049 RGD
involved in positive regulation of cellular extravasation IMP
IMP: Inferred from mutant phenotype
10861081 RGD
involved in positive regulation of leukocyte migration IMP
IMP: Inferred from mutant phenotype
8248808 RGD
Cellular Component GO Annotation Evidence Références Source
located in cell surface IDA
IDA: Inferred from direct assay
18466611 RGD
located in ruffle IDA
IDA: Inferred from direct assay
9148965 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

platelet endothelial cell adhesion molecule

  • PECAM-1

  • platelet/endothelial cell adhesion molecule 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P3444 CD31 99.33% Unkown
HY-P3444A CD31 TFA / Unkown
HY-RS10315 PECAM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174546 Human PECAM1 mRNA / Unkown
HY-RS17929 Pecam1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24399 Pecam1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P990277 Anti-Mouse CD31/PECAM-1 Antibody (390) Inhibitor ≥95.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pecam1 NCBI NCBI:5175