Parp4 - poly (ADP-ribose) polymerase family, member 4 Gene

Also Known as PH5P; p193; ARTD4; Gm743; PARPL; VPARP; PARP-4; VAULT3; Adprtl1; C030027K23Rik; E230037B21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 328417

About Parp4

Chromosome 14: 56,813,076-56,897,251 forward strand.GRCm39:CM001007.3

This gene has 2 transcripts (splice variants), 186 orthologues, 11 paralogues and is associated with 6 phenotypes. Ubiquitous expression in bladder adult (RPKM 5.9), placenta adult (RPKM 4.9) and 26 other tissues.

Summary

Predicted to enable NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Predicted to be involved in several processes, including inflammatory response; protein mono-ADP-ribosylation; and regulation of Telomerase activity. Predicted to act upstream of or within protein ADP-ribosylation. Predicted to be located in cytosol and spindle microtubule. Orthologous to human PARP4 (poly(ADP-ribose) polymerase family member 4). [provided by Alliance of Genome Resources, Apr 2022]

Parp4 Products (1)

mRNA Protein Name
NM_001145978.2 NP_001139450.2 protein mono-ADP-ribosyltransferase PARP4

Parp4 Protein Structure

BRCT

BRCT: cl00038 (4 - 87)

parp_like

parp_like: cd01437 (243 - 556)

VIT

VIT: pfam08487 (615 - 725)

VWA

VWA: smart00327 (869 - 1025)

Drf_FH1

Drf_FH1: cl25521 (1371 - 1607)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1969 a.a.
Protein Preferred Names Protein Names

protein mono-ADP-ribosyltransferase PARP4

  • ADP-ribosyltransferase (NAD+

  • poly (ADP-ribose) polymerase)-like 1

  • ADP-ribosyltransferase diphtheria toxin-like 4

  • mVparp

  • poly [ADP-ribose] polymerase 4

  • vault poly(ADP-ribose) polymerase

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-10619 Niraparib Inhibitor 99.96% Yes
HY-10619A Niraparib hydrochloride Inhibitor 99.41% Yes
HY-10619B Niraparib tosylate Inhibitor 99.99% Yes
HY-10619E Niraparib tosylate hydrate Inhibitor 99.97% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-150207 RBN-3143 Inhibitor 99.29% Phase 1

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136979 RBN012759 Inhibitor 99.33% Unkown
HY-148566 OUL232 Inhibitor 99.86% Unkown
HY-148754 PARP10-IN-3 Inhibitor 98.72% Unkown
HY-148753 PARP10-IN-2 Inhibitor 98.07% Unkown
HY-155993 YCH1899 Inhibitor 99.39% Unkown
HY-W294889 OUL245 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Parp4 NCBI NCBI:143