NTM - neurotrimin Gene

Also Known as HNT; NTRI; CEPU-1; IGLON2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 50863

About NTM

Cytogenetic location: 11q25 Genomic coordinates (GRCh38): 11:131,370,615-132,336,822 (from NCBI)

This gene has 23 transcripts (splice variants), 219 orthologues and 5 paralogues. Biased expression in brain (RPKM 12.0), lung (RPKM 3.5) and 5 other tissues.

Summary

This gene encodes a member of the IgLON (LAMP, OBCAM, Ntm) family of immunoglobulin (Ig) domain-containing glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecules. The encoded protein may promote neurite outgrowth and adhesion via a homophilic mechanism. This gene is closely linked to a related family member, opioid binding protein/cell adhesion molecule-like (OPCML), on chromosome 11. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]

NTM Products (19)

mRNA Protein Name
NM_001048209.2 NP_001041674.1 neurotrimin isoform 2 precursor
NM_001144058.2 NP_001137530.1 neurotrimin isoform 3 precursor
NM_001144059.3 NP_001137531.1 neurotrimin isoform 4 precursor
NM_001352001.2 NP_001338930.1 neurotrimin isoform 5 precursor
NM_001352002.2 NP_001338931.1 neurotrimin isoform 6 precursor
NM_001352003.2 NP_001338932.1 neurotrimin isoform 7 precursor
NM_001352004.2 NP_001338933.1 neurotrimin isoform 8 precursor
NM_001352005.2 NP_001338934.1 neurotrimin isoform 9 precursor
NM_001352006.2 NP_001338935.1 neurotrimin isoform 10
NM_001352007.2 NP_001338936.1 neurotrimin isoform 11
NM_001352008.2 NP_001338937.1 neurotrimin isoform 12
NM_001352009.2 NP_001338938.1 neurotrimin isoform 13
NM_001386964.1 NP_001373893.1 neurotrimin isoform 14
NM_001386965.1 NP_001373894.1 neurotrimin isoform 15
NM_001386966.1 NP_001373895.1 neurotrimin isoform 16
NM_001386967.1 NP_001373896.1 neurotrimin isoform 17
NM_001386968.1 NP_001373897.1 neurotrimin isoform 5
NM_001386969.1 NP_001373898.1 neurotrimin isoform 16
NM_016522.3 NP_057606.1 neurotrimin isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NTM Protein Structure

I-set

I-set: Immunoglobulin I-set domain (38 - 132)

I-set

I-set: Immunoglobulin I-set domain (136 - 215)

I-set

I-set: Immunoglobulin I-set domain (230 - 310)

  • 0
  • 100
  • 200
  • 300
  • 344 a.a.
Protein Preferred Names Protein Names

neurotrimin

  • IgLON family member 2

NTM Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Validated Y2H
25416956
Intra
NTM Q9P121 CCKBR Homo sapiens P32239
Y2H Array
25416956
Intra
NTM Q9P121 C19orf47 Homo sapiens Q8N9M1
Y2H Array
25416956
Intra
NTM Q9P121 C19orf47 Homo sapiens Q8N9M1
Validated Y2H
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
NTM Q9P121 LSAMP Homo sapiens Q13449
Protein Array
21982860
Intra
NTM Q9P121 NEGR1 Homo sapiens Q7Z3B1
Protein Array
21982860
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Validated Y2H
25416956
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
25416956
Intra
NTM Q9P121 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
31515488
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NTM Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71154 Neurotrimin Protein, Human (HEK293, His) Q9P121-3 (G34-L316) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74702 Neurotrimin Protein, Human (HEK293, Fc) Q9P121-1 (G34-G312) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Juvenile Pilocytic Astrocytoma
Jacobsen Syndrome

  • Chromosome 11q Deletion Syndrome

  • Partial 11q Monosomy Syndrome

  • Jacobsen Distal 11q Deletion Syndrome

  • JBS

  • 11q Partial Monosomy Syndrome

  • Chromosome 11q Deletion

  • 11q Deletion

  • 11q Monosomy

  • Deletion 11q

  • Monosomy 11q

  • Partial Monosomy 11q

  • 11q Deletion Disorder

  • 11q Deletion Syndrome

  • 11q Terminal Deletion Disorder

  • 11q- Deletion Syndrome

  • 11q23 Deletion Disorder

  • Jacobsen Thrombocytopenia

  • 11q Terminal Deletion Syndrome

  • Del(11)(Q23.3)

  • Del(11)(Qter)

  • Distal Deletion 11q

  • Distal Monosomy 11q

  • Monosomy 11qter

  • Telomeric Deletion 11q

  • Paris-Trousseau Thrombocytopenia
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-182783 JNJ-10450232 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (9)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-170224 dNTP Mixture,10 mM Solution,PCR Grade 99.0% Unkown
HY-12930 SPR719 Inhibitor 99.39% Unkown
HY-148478 MMV688845 Inhibitor 99.03% Unkown
HY-172263 KU13 Inhibitor / Unkown
HY-RS09619 NTM Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-159899 DHFR-IN-22 Inhibitor / Unkown
HY-170519 K13787 Inhibitor / Unkown
HY-RS18741 Ntm Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25228 Ntm Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus NTM VGNC VGNC:81966
Mus musculus NTM MGD MGI:2446259
Canis familiaris NTM VGNC VGNC:44005
Bos taurus NTM VGNC VGNC:32302
Macaca mulatta NTM VGNC VGNC:75425
Rattus norvegicus NTM RGD RGD:620958
Others NTM NCBI