2. GPCR/G Protein
  3. Adenosine Receptor
  4. JNJ-10450232

NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain.

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JNJ-10450232

JNJ-10450232 Chemical Structure

CAS No. : 862248-40-6

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JNJ-10450232 Related Antibodies

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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Description

NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain[1].

IC50 & Target[1]

A3R

 

In Vitro

NTM-006 binds to human full-length A3AR with a -CDOCKER ENERGY score of 19.31 kcal/mol, via π-π stacking with Phe168 and π-alkyl interactions with select receptor residues[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ-10450232 Related Antibodies
In Vivo

NTM-006 (30-300 mg/kg, s.c., single dose) shows antinociceptive activity in Acetic acid (HY-Y0319)-induced writhing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Acetic acid-induced writhing mice (Mus musculus)[1]
Dosage: 30, 100, 300 mg/kg
Administration: s.c., single dose
Result: Inhibited inhibition rate.
Clinical Trial
Molecular Weight

217.22

Formula

C11H11N3O2
CAS No.
SMILES

CC1=CC(C(NC2=CC=C(O)C=C2)=O)=NN1
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Purity & Documentation
References
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JNJ-10450232 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-10450232862248-40-6NTM-006JNJ10450232JNJ 10450232NTM006NTM 006Adenosine ReceptorP1 receptorVal72cancer-related painLeu246A3ARLeu264miceIle268chronic neuropathic painPhe168adenosine A3 receptorInhibitorinhibitorinhibit

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