862248-40-6
Chemical Structure
JNJ-10450232
Synonym(s): NTM-006
- CAS No.: 862248-40-6
- Formula:C11H11N3O2
- Molecular Weight:217.22
InChIKey: MHEAJCHALAVTEX-UHFFFAOYSA-N
SMILES: CC1=CC(C(NC2=CC=C(O)C=C2)=O)=NN1
Biological Activity: NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain[1].
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JNJ-10450232 | NTM-006 is a selective and brain-penetrant adenosine A3 receptor (A3AR) agonist. NTM-006 selectively interacts with adenosine A3AR via π-π stacking with Phe168 and π-alkyl interactions receptor residues. NTM-006 inhibits Acetic acid (HY-Y0319)-induced writhing responses in mice. NTM-006 can be used for the research of chronic neuropathic pain, cancer-related pain, osteoarthritis-associated pain. | |||||||||||||||||||||
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Keywords
