REV1 - REV1 DNA directed polymerase Gene

Homo sapiens

Also known as REV1L; AIBP80

Gene ID: 51455 | Gene type: protein coding

About REV1

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,400,477-99,490,202 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

REV1 Products(7)

mRNA	Protein	Name
NM_001037872.3	NP_001032961.1	DNA repair protein REV1 isoform 2
NM_001321454.2	NP_001308383.1	DNA repair protein REV1 isoform 3
NM_001321455.2	NP_001308384.1	DNA repair protein REV1 isoform 4
NM_001321458.2	NP_001308387.1	DNA repair protein REV1 isoform 5
NM_001321459.2	NP_001308388.1	DNA repair protein REV1 isoform 6
NM_001321460.2	NP_001308389.1	DNA repair protein REV1 isoform 6
NM_016316.4	NP_057400.1	DNA repair protein REV1 isoform 1

REV1 Protein Structure

BRCT

IMS

IMS_C

0
200
400
600
800
1000
1251 a.a.

Protein Preferred Names

Protein Names

DNA repair protein REV1

REV1 homolog

Related Diseases

Diseases

Alias

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Fanconi Anemia, Complementation Group F

Fanconi Anemia Complementation Group F

FANCF

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Aplastic Anemia

Aplastic Anemia, Susceptibility To	Anemia Aplastic
Idiopathic Aplastic Anemia	Secondary Aplastic Anemia
Idiopathic Bone Marrow Failure	Aplastic Anemia Idiopathic
AA	Anemia, Aplastic
Aplastic Anemia, Idiopathic	Erythroid Aplasia
Aa - [Aplastic Anaemia]	Haematopoietic Aplasia
Aleukia Haemorrhagica	Anaemia Due To Decreased Red Cell Production
Aplasia Bone Marrow	Aplastic Bone Marrow
Hypoplastic Anaemia Nos	Myeloid Bone Marrow Aplasia
Pancytopenia	Panhaematopenia
Hypoproliferative Anaemia	Medullary Hypoplasia
Red Blood Cells Hypoplastic Anaemia	Panmyelophthisis
Panhemocytopenia	Refractive Hypoproliferative Anaemia
Toxic Anaemia	Toxic Aplastic Anaemia
Aplastic Anaemia Due To Toxic Cause	Idiopathic Aplastic Anaemia Nos

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126214	JH-RE-06	Inhibitor	99.81%	Unkown
HY-RS11861	REV1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	REV1	RGD	RGD:1306715
Canis familiaris	REV1	VGNC	VGNC:45487
Felis catus	REV1	VGNC	VGNC:64579
Macaca mulatta	REV1	VGNC	VGNC:106209
Bos taurus	REV1	VGNC	VGNC:33882
Mus musculus	REV1	MGD	MGI:1929074
Others	REV1	NCBI

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