REV1 - REV1 DNA directed polymerase Gene

Also Known as REV1L; AIBP80

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51455

About REV1

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,400,477-99,490,202 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 5 paralogues. Ubiquitous expression in endometrium (RPKM 6.5), testis (RPKM 6.4) and 25 other tissues.

Summary

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. The Rev1 proteins contain a BRCT domain, which is important in protein-protein interactions. A suggested role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis (TLS) of damaged DNA. [provided by RefSeq, Mar 2016]

REV1 Products (7)

mRNA Protein Name
NM_001037872.3 NP_001032961.1 DNA repair protein REV1 isoform 2
NM_001321454.2 NP_001308383.1 DNA repair protein REV1 isoform 3
NM_001321455.2 NP_001308384.1 DNA repair protein REV1 isoform 4
NM_001321458.2 NP_001308387.1 DNA repair protein REV1 isoform 5
NM_001321459.2 NP_001308388.1 DNA repair protein REV1 isoform 6
NM_001321460.2 NP_001308389.1 DNA repair protein REV1 isoform 6
NM_016316.4 NP_057400.1 DNA repair protein REV1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11485998 GOA
Biological Process GO Annotation Evidence References Source
involved in response to UV IDA
IDA: Inferred from direct assay
11485998 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REV1 Protein Structure

BRCT

BRCT: BRCA1 C Terminus (BRCT) domain (46 - 118)

IMS

IMS: impB/mucB/samB family (422 - 621)

IMS_C

IMS_C: impB/mucB/samB family C-terminal domain (700 - 825)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1251 a.a.
Protein Preferred Names Protein Names

DNA repair protein REV1

  • REV1 homolog

REV1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
REV1 Q9UBZ9 FAAP20 Homo sapiens Q6NZ36
NMR
26318859
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Fanconi Anemia, Complementation Group F

  • Fanconi Anemia Complementation Group F

  • FANCF
Interstitial Nephritis, Karyomegalic

  • Karyomegalic Interstitial Nephritis

  • KMIN

  • Kin

  • Systemic Karyomegaly

  • Karyomegalic Tubulointerstitial Nephritis

  • Ktn
Aplastic Anemia

  • Aplastic Anemia, Susceptibility To

  • Anemia Aplastic

  • Idiopathic Aplastic Anemia

  • Secondary Aplastic Anemia

  • Idiopathic Bone Marrow Failure

  • Aplastic Anemia Idiopathic

  • AA

  • Anemia, Aplastic

  • Aplastic Anemia, Idiopathic

  • Erythroid Aplasia

  • Aa - [Aplastic Anaemia]

  • Haematopoietic Aplasia

  • Aleukia Haemorrhagica

  • Anaemia Due To Decreased Red Cell Production

  • Aplasia Bone Marrow

  • Aplastic Bone Marrow

  • Hypoplastic Anaemia Nos

  • Myeloid Bone Marrow Aplasia

  • Pancytopenia

  • Panhaematopenia

  • Hypoproliferative Anaemia

  • Medullary Hypoplasia

  • Red Blood Cells Hypoplastic Anaemia

  • Panmyelophthisis

  • Panhemocytopenia

  • Refractive Hypoproliferative Anaemia

  • Toxic Anaemia

  • Toxic Aplastic Anaemia

  • Aplastic Anaemia Due To Toxic Cause

  • Idiopathic Aplastic Anaemia Nos
Fanconi Anemia, Complementation Group A

  • Fanconi Anemia

  • Fanconi Pancytopenia

  • Fanconi Anemia Complementation Group A

  • FANCA

  • Fa

  • Fanconi Panmyelopathy

  • Fanconi'S Anemia

  • Fanconi Anaemia

  • Fanconi'S Anaemia

  • Fanconi Hypoplastic Anemia

  • Estren-Dameshek Variant Of Fanconi Anemia

  • Estren-Dameshek Variant Of Fanconi Pancytopenia

  • Fanconi Anemia Estren-Dameshek Variant

  • Fanconis Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-126214 JH-RE-06 Inhibitor 99.87% Unkown
HY-117664 PNR-7-02 Inhibitor 98.0% Unkown
HY-126214S JH-RE-06-d6 Inhibitor 98.04% Unkown
HY-RS20810 Rev1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115465 Rev1-CT/RIR PPI-IN-1 / Unkown
HY-185266 Rev1-CT/RIR PPI-IN-2 Inhibitor / Unkown
HY-RS11861 REV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-117846 MLAF50 Agonist / Unkown
HY-RS20597 Slc7a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27324 Rev1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus REV1 RGD RGD:1306715
Canis familiaris REV1 VGNC VGNC:45487
Felis catus REV1 VGNC VGNC:64579
Macaca mulatta REV1 VGNC VGNC:106209
Bos taurus REV1 VGNC VGNC:33882
Mus musculus REV1 MGD MGI:1929074
Others REV1 NCBI