Rev1-CT/RIR PPI-IN-1
Rev1-CT/RIR PPI-IN-1 (Compound 1) is a thiophene-based compound. Rev1-CT/RIR PPI-IN-1 can specifically disrupt the protein-protein interaction between Rev1-CT and RIR, with an IC50 value of 2.5 µM. Rev1-CT/RIR PPI-IN-1 can enhance chemosensitivity and reduce the mutation rate in Cisplatin (HY-17394)-sensitive HT-1080 cells. Rev1-CT/RIR PPI-IN-1 can be used for tumor research.
For research use only. We do not sell to patients.
- CAS No.: 908510-73-6
- Formula: C21H29N3O3S
- Molecular Weight:403.54
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | GI50 |
>100 μM
Compound: 1
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Growth inhibition of cisplatin-resistant human U2OS cells after 72 hrs by MTS assay
Growth inhibition of cisplatin-resistant human U2OS cells after 72 hrs by MTS assay
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[PMID: 30037752] |
| U2OS | GI50 |
15.3 μM
Compound: 1
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Potentiation of cisplatin-induced cytotoxicity in cisplatin-resistant human U2OS cells assessed as cisplatin GI50 at 50 uM after 72 hrs by MTS assay (Rvb = 23.9 +/- 1.9 uM)
Potentiation of cisplatin-induced cytotoxicity in cisplatin-resistant human U2OS cells assessed as cisplatin GI50 at 50 uM after 72 hrs by MTS assay (Rvb = 23.9 +/- 1.9 uM)
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[PMID: 30037752] |
| U2OS | GI50 |
24.4 μM
Compound: 1
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Potentiation of cisplatin-induced cytotoxicity in cisplatin-resistant human U2OS cells assessed as cisplatin GI50 at 25 uM after 72 hrs by MTS assay (Rvb = 23.9 +/- 1.9 uM)
Potentiation of cisplatin-induced cytotoxicity in cisplatin-resistant human U2OS cells assessed as cisplatin GI50 at 25 uM after 72 hrs by MTS assay (Rvb = 23.9 +/- 1.9 uM)
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[PMID: 30037752] |
Chemical Information
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CAS No. 908510-73-6
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Molecular Weight 403.54
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Formula C21H29N3O3S
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SMILES
O=C(C1CCN(C(C)=O)CC1)NC2=C(C(NC3CC3)=O)C(CCC(C)C4)=C4S2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Rev1-CT/RIR PPI-IN-1 Related Classifications
HY-115465 Related Classifications
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