TOLLIP - toll interacting protein Gene

Homo sapiens

Also known as IL-1RAcPIP

Gene ID: 54472 | Gene type: protein coding

About TOLLIP

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,274,371-1,309,632 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like Receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TOLLIP Products(5)

mRNA	Protein	Name
NM_001318512.2	NP_001305441.1	toll-interacting protein isoform 2
NM_001318514.2	NP_001305443.1	toll-interacting protein isoform 3
NM_001318515.2	NP_001305444.1	toll-interacting protein isoform 5
NM_001318516.2	NP_001305445.1	toll-interacting protein isoform 4
NM_019009.4	NP_061882.2	toll-interacting protein isoform 1

TOLLIP Protein Structure

CUE

0
100
200
274 a.a.

Protein Preferred Names

Protein Names

toll-interacting protein

adapter protein

Recombinant TOLLIP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71373	TOLLIP Protein, Human (His)	Q9H0E2 (A2-P274)	≥95%

Related Diseases

Diseases

Alias

Tick Paralysis

Idiopathic Interstitial Pneumonia

Hamman-Rich Syndrome	Diffuse Idiopathic Pulmonary Fibrosis
Idiopathic Fibrosing Alveolitis	Ipf
Idiopathic Interstitial Pneumonias	Idiopathic Interstitial Pneumonia, Not Otherwise Specified
Pulmonary Fibrosis

Acute Vascular Insufficiency Of Intestine

Acute Gastrointestinal Tract Vascular Insuffic.	Acute Git Vascular Insuffic.
Acute Intestinal Ischemia	Acute Intestinal Vascular Insufficiency

Lymphoproliferative Syndrome, X-Linked, 1

Lymphomatoid Papulosis	Duncan Disease
Purtilo Syndrome	X-Linked Lymphoproliferative Syndrome
Xlp	X-Linked Lymphoproliferative Disease
XLP1	Lyp
Lymphoproliferative Disease, X-Linked	Xlpd
X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency	Ebv Infection, Severe, Susceptibility To
Ebvs	Immunodeficiency 5
Imd5	X-Linked Lymphoproliferative Syndrome 1
Epstein-Barr Virus Infection, Familial Fatal	Ebv Infection, Severe
Infectious Mononucleosis, Severe	Infectious Mononucleosis, Severe, Susceptibility To
Immunodeficiency, X-Linked Progressive Combined Variable	Epstein Barr Virus Infection, Familial Fatal
X-Linked Progressive Combined Variable Immunodeficiency 5	Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males
Familial Fatal Epstein-Barr Infection	Severe Susceptibility To Ebv Infection
Severe Susceptibility To Infectious Mononucleosis	Sap Deficiency
Sh2d1a/Slam-Associated Protein Deficiency	X-Linked Lymphoproliferative Syndrome Type 1
X-Linked Progressive Combined Variable Immunodeficiency	Lymphoproliferative Syndrome, X-Linked
Sap	X-Linked Lymphoproliferative Disorder

Nonspecific Interstitial Pneumonia

Nsip	Non-Specific Interstitial Pneumonia
Non-Specific Idiopathic Interstitial Pneumonia	Non-Specific Interstitial Pneumonia Nos

Interstitial Lung Disease 2

Idiopathic Pulmonary Fibrosis	Ipf
Fibrocystic Pulmonary Dysplasia	Pulmonary Fibrosis, Idiopathic
Pulmonary Fibrosis, Idiopathic, Susceptibility To	Cryptogenic Fibrosing Alveolitis
ILD2	Idiopathic Pulmonary Fibrosis, Familial
Fibrosing Alveolitis, Cryptogenic	Uip
Fibrosing Alveolitis	Interstitial Pneumonitis, Usual
Familial Idiopathic Pulmonary Fibrosis	Idiopathic Fibrosing Alveolitis, Chronic Form
Usual Interstitial Pneumonia	Fibrosing Alveolitis Cryptogenic
Hamman-Rich Disease	Idiopathic Pulmonary Fibrosis Familial
Interstitial Pneumonitis Usual	Fibrosis Idiopathic Pulmonary
Fibrosis, Pulmonary, Idiopathic	Hamman-Rich Syndrome
Chronic Idiopathic Pulmonary Fibrosis	Acute Interstitial Pneumonia
Interstitial Pulmonary Fibrosis	Ipf - [Idiopathic Pulmonary Fibrosis]
Idiopathic Lung Fibrosis	Fibrosing Lung Disease
Pulmonary Fibrosis Nos	Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14875	TOLLIP Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TOLLIP	RGD	RGD:1304676
Felis catus	TOLLIP	VGNC	VGNC:66440
Bos taurus	TOLLIP	VGNC	VGNC:36216
Macaca mulatta	TOLLIP	VGNC	VGNC:79035
Canis familiaris	TOLLIP	VGNC	VGNC:52056
Mus musculus	TOLLIP	MGD	MGI:1891808
Others	TOLLIP	NCBI

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