TOLLIP - toll interacting protein Gene

Also Known as IL-1RAcPIP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54472

About TOLLIP

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:1,274,371-1,309,632 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in brain (RPKM 31.0), testis (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a ubiquitin-binding protein that interacts with several Toll-like Receptor (TLR) signaling cascade components. The encoded protein regulates inflammatory signaling and is involved in interleukin-1 receptor trafficking and in the turnover of IL1R-associated kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]

TOLLIP Products (5)

mRNA	Protein	Name
NM_001318512.2	NP_001305441.1	toll-interacting protein isoform 2
NM_001318514.2	NP_001305443.1	toll-interacting protein isoform 3
NM_001318515.2	NP_001305444.1	toll-interacting protein isoform 5
NM_001318516.2	NP_001305445.1	toll-interacting protein isoform 4
NM_019009.4	NP_061882.2	toll-interacting protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables Toll-like receptor binding	IPI IPI: Inferred from physical interaction	11441107	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	10854325	GOA
enables molecular adaptor activity	IDA IDA: Inferred from direct assay	10854325	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11397809	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in epithelial cell differentiation	IEP IEP: Inferred from expression pattern	21492153	GOA
involved in interleukin-1-mediated signaling pathway	IDA IDA: Inferred from direct assay	10854325	GOA
involved in phosphorylation	IDA IDA: Inferred from direct assay	1085432	GOA
involved in protein localization to endosome	IDA IDA: Inferred from direct assay	16412388	GOA
involved in signal transduction	IPI IPI: Inferred from physical interaction	11441107	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	10854325	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOLLIP Protein Structure

CUE

0
100
200
274 a.a.

Protein Preferred Names	Protein Names
toll-interacting protein	adapter protein

TOLLIP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	TOLLIP	Q9H0E2	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	KRTAP13-3	Homo sapiens	Q3SY46	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP19-7	Homo sapiens	Q3SYF9	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	TOLLIP	Q9H0E2	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	MEDAG	Homo sapiens	Q5VYS4	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	MEDAG	Homo sapiens	Q5VYS4	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	MSS51	Homo sapiens	Q4VC12	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	MSS51	Homo sapiens	Q4VC12	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP6-2	Homo sapiens	Q3LI66	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	USP54	Homo sapiens	Q70EL1-9	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	USP54	Homo sapiens	Q70EL1-9	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	ACTMAP	Homo sapiens	Q5BKX5-3	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP15-1	Homo sapiens	Q3LI76	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674-2	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674-2	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	KRTAP6-1	Homo sapiens	Q3LI64	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784-2	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784-2	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Validated Y2H	32296183
Intra	TOLLIP	Q9H0E2	RBFOX1	Homo sapiens	Q9NWB1-5	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7-2	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7-2	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	CIMIP2B	Homo sapiens	A8MTA8-2	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	Anti Tag CoIP	33961781
Intra	TOLLIP	Q9H0E2	CSTF1	Homo sapiens	Q05048	BioID	34524948
Intra	TOLLIP	Q9H0E2	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	KRTAP7-1	Homo sapiens	Q8IUC3	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	WRNIP1	Homo sapiens	Q96S55	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Y2H Pooling	32814053
Intra	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Validated Y2H	32814053
Intra	TOLLIP	Q9H0E2	DCTN1	Homo sapiens	Q14203-5	Y2H Array	32814053
Intra	TOLLIP	Q9H0E2	PRPF39	Homo sapiens	Q86UA1	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	PRPF39	Homo sapiens	Q86UA1	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	MVP	Homo sapiens	Q14764	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	MVP	Homo sapiens	Q14764	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TTC9C	Homo sapiens	Q8N5M4	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	TTC9C	Homo sapiens	Q8N5M4	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	PEG10	Homo sapiens	Q86TG7	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
Intra	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7	Y2H Pooling	20936779
Intra	TOLLIP	Q9H0E2	TOM1L2	Homo sapiens	Q6ZVM7	Anti Tag CoIP	35271311
Intra	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	RHOXF2	Homo sapiens	Q9BQY4	Y2H Pooling	16189514
Intra	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	TOLLIP	Q9H0E2	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	TOLLIP	Q9H0E2	IRAK2	Homo sapiens	O43187	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	ZRANB1	Homo sapiens	Q9UGI0	Validated Y2H	32296183
Intra	TOLLIP	Q9H0E2	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	MSX2	Homo sapiens	P35548	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	MSX2	Homo sapiens	P35548	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	33961781
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	21903422
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Anti Tag CoIP	35271311
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Y2H Pooling	20936779
Intra	TOLLIP	Q9H0E2	TOM1L1	Homo sapiens	O75674	Y2H Array	21988832
Intra	TOLLIP	Q9H0E2	MAP1LC3A	Homo sapiens	Q9H492	IF	25042851
Intra	TOLLIP	Q9H0E2	MAP1LC3A	Homo sapiens	Q9H492	Anti Tag CoIP	25042851
Intra	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	TOLLIP	Q9H0E2	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	RBPMS	Homo sapiens	Q93062	Validated Y2H	25416956
Intra	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Y2H Prey Pooling	25416956
Intra	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Y2H Array	31515488
Intra	TOLLIP	Q9H0E2	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	25416956
Intra	TOLLIP	Q9H0E2	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Y2H Array	25416956
Intra	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Anti Tag CoIP	35271311
Intra	TOLLIP	Q9H0E2	TOM1	Homo sapiens	O60784	Validated Y2H	25416956
Intra	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Validated Y2H	32296183
Intra	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	STN1	Homo sapiens	Q9H668	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	DAB1	Homo sapiens	O75553	Validated Y2H	25416956
Intra	TOLLIP	Q9H0E2	DAB1	Homo sapiens	O75553	Y2H Array	25416956
Intra	TOLLIP	Q9H0E2	ATXN1	Homo sapiens	P54253	Y2H	16713569
Intra	TOLLIP	Q9H0E2	PHAF1	Homo sapiens	Q9BSU1	Y2H Prey Pooling	32296183
Intra	TOLLIP	Q9H0E2	PHAF1	Homo sapiens	Q9BSU1	Y2H Array	32296183
Intra	TOLLIP	Q9H0E2	DZIP3	Homo sapiens	Q86Y13	Anti Tag CoIP	21903422

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TOLLIP Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P71373	TOLLIP Protein, Human (His)	Q9H0E2-1 (A2-P274)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Tick Paralysis
Idiopathic Interstitial Pneumonia	Hamman-Rich Syndrome Diffuse Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis Ipf Idiopathic Interstitial Pneumonias Idiopathic Interstitial Pneumonia, Not Otherwise Specified Pulmonary Fibrosis
Acute Vascular Insufficiency Of Intestine	Acute Gastrointestinal Tract Vascular Insuffic. Acute Git Vascular Insuffic. Acute Intestinal Ischemia Acute Intestinal Vascular Insufficiency
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Nonspecific Interstitial Pneumonia	Nsip Non-Specific Interstitial Pneumonia Non-Specific Idiopathic Interstitial Pneumonia Non-Specific Interstitial Pneumonia Nos
Interstitial Lung Disease 2	Idiopathic Pulmonary Fibrosis Ipf Fibrocystic Pulmonary Dysplasia Pulmonary Fibrosis, Idiopathic Pulmonary Fibrosis, Idiopathic, Susceptibility To Cryptogenic Fibrosing Alveolitis ILD2 Idiopathic Pulmonary Fibrosis, Familial Fibrosing Alveolitis, Cryptogenic Uip Fibrosing Alveolitis Interstitial Pneumonitis, Usual Familial Idiopathic Pulmonary Fibrosis Idiopathic Fibrosing Alveolitis, Chronic Form Usual Interstitial Pneumonia Fibrosing Alveolitis Cryptogenic Hamman-Rich Disease Idiopathic Pulmonary Fibrosis Familial Interstitial Pneumonitis Usual Fibrosis Idiopathic Pulmonary Fibrosis, Pulmonary, Idiopathic Hamman-Rich Syndrome Chronic Idiopathic Pulmonary Fibrosis Acute Interstitial Pneumonia Interstitial Pulmonary Fibrosis Ipf - [Idiopathic Pulmonary Fibrosis] Idiopathic Lung Fibrosis Fibrosing Lung Disease Pulmonary Fibrosis Nos Fibrosing Pneumonitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14875	TOLLIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21207	Tollip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27723	Tollip Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TOLLIP	RGD	RGD:1304676
Felis catus	TOLLIP	VGNC	VGNC:66440
Bos taurus	TOLLIP	VGNC	VGNC:36216
Macaca mulatta	TOLLIP	VGNC	VGNC:79035
Canis familiaris	TOLLIP	VGNC	VGNC:52056
Mus musculus	TOLLIP	MGD	MGI:1891808
Others	TOLLIP	NCBI