CSTF1 - cleavage stimulation factor subunit 1 Gene

Also Known as CstF-50; CstFp50

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1477

About CSTF1

Cytogenetic location: 20q13.2-q13.31 Genomic coordinates (GRCh38): 20:56,392,379-56,406,362 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 12.7), lymph node (RPKM 8.5) and 25 other tissues.

Summary

This gene encodes one of three subunits which combine to form cleavage stimulation factor (CSTF). CSTF is involved in the polyadenylation and 3'end cleavage of pre-mRNAs. Similar to mammalian G protein beta subunits, this protein contains transducin-like repeats. Several transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

CSTF1 Products (3)

mRNA Protein Name
NM_001033521.2 NP_001028693.1 cleavage stimulation factor subunit 1
NM_001033522.2 NP_001028694.1 cleavage stimulation factor subunit 1
NM_001324.3 NP_001315.1 cleavage stimulation factor subunit 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10477523 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CSTF1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (105 - 134)

WD40

WD40: WD domain, G-beta repeat (166 - 201)

WD40

WD40: WD domain, G-beta repeat (261 - 290)

WD40

WD40: WD domain, G-beta repeat (308 - 334)

WD40

WD40: WD domain, G-beta repeat (395 - 424)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 431 a.a.
Protein Preferred Names Protein Names

cleavage stimulation factor subunit 1

  • CF-1 50 kDa subunit

CSTF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CSTF1 Q05048 BARD1 Homo sapiens Q99728
Y2H
10477523
Cross: Cross-species interaction Intra: Intraspecies interaction

CSTF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811020 CstF-50 Antibody WB, IHC-P Human, Mouse, Rat
HY-P89865 CstF-50 Antibody (YA9209) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Cockayne Syndrome

  • Cockayne'S Syndrome

  • Dwarfism-Retinal Atrophy-Deafness Syndrome

  • Neill-Dingwall Syndrome

  • Progeria-Like Syndrome

  • Progeroid Nanism

  • Cs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03273 CSTF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CSTF1 VGNC VGNC:71535
Felis catus CSTF1 VGNC VGNC:61239
Bos taurus CSTF1 VGNC VGNC:27780
Rattus norvegicus CSTF1 RGD RGD:1309267
Mus musculus CSTF1 MGD MGI:1914587
Canis familiaris CSTF1 VGNC VGNC:39682
Others CSTF1 NCBI