AURKC - aurora kinase C Gene

Also Known as AIE2; AIK3; ARK3; AurC; SPGF5; STK13; HEL-S-90; aurora-C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6795

About AURKC

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,231,023-57,235,548 (from NCBI)

This gene has 7 transcripts (splice variants), 99 orthologues, 2 paralogues and is associated with 2 phenotypes. Biased expression in testis (RPKM 14.8), brain (RPKM 1.0) and 1 other tissue.

Summary

This gene encodes a member of the Aurora subfamily of serine/threonine protein kinases. The encoded protein is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere proteins and may play a role in organizing microtubules in relation to centrosome/spindle function during Mitosis. This gene is overexpressed in several Cancer cell lines, suggesting an involvement in oncogenic signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AURKC Products (4)

mRNA Protein Name
NM_001015878.2 NP_001015878.1 aurora kinase C isoform 1
NM_001015879.2 NP_001015879.1 aurora kinase C isoform 2
NM_003160.3 NP_003151.2 aurora kinase C isoform 3
XM_047439253.1 XP_047295209.1 aurora kinase C isoform X1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables protein kinase activity IDA
IDA: Inferred from direct assay
15670791 GOA
Biological Process GO Annotation Evidence References Source
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
15670791 GOA
Cellular Component GO Annotation Evidence References Source
located in condensed chromosome IDA
IDA: Inferred from direct assay
15670791 GOA
located in midbody IDA
IDA: Inferred from direct assay
15670791 GOA
located in spindle midzone IDA
IDA: Inferred from direct assay
15670791 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AURKC Protein Structure

Pkinase

Pkinase: Protein kinase domain (43 - 293)

  • 0
  • 100
  • 200
  • 309 a.a.
Protein Preferred Names Protein Names

aurora kinase C

  • ARK-3

  • aurora 3

  • aurora-related kinase 3

  • aurora/IPL1-related kinase 3

  • aurora/IPL1/EG2 protein 2

  • epididymis secretory protein Li 90

  • serine/threonine kinase 13 (aurora/IPL1-like)

  • serine/threonine-protein kinase 13

  • serine/threonine-protein kinase aurora-C

AURKC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AURKC Q9UQB9 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra
AURKC Q9UQB9 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Pull Down
32707033
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
27332895
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Tag CoIP
33961781
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
IF
27332895
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Anti Bait CoIP
27332895
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Pull Down
27332895
Intra
AURKC Q9UQB9 INCENP Homo sapiens Q9NQS7
Protein Kinase Assay
27332895
Intra
AURKC Q9UQB9 BIRC7 Homo sapiens Q96CA5
Y2H Prey Pooling
32296183
Intra
AURKC Q9UQB9 BIRC7 Homo sapiens Q96CA5
Y2H Array
32296183
Intra
AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Pull Down
27332895
Intra
AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Anti Bait CoIP
27332895
Intra
AURKC Q9UQB9 BIRC5 Homo sapiens O15392
IF
27332895
Intra
AURKC Q9UQB9 BIRC5 Homo sapiens O15392
Anti Tag CoIP
27332895
Intra
AURKC Q9UQB9 OTX2 Homo sapiens P32243-2
Y2H Prey Pooling
32296183
Intra
AURKC Q9UQB9 OTX2 Homo sapiens P32243-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Male Infertility With Spermatogenesis Disorder
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Nystagmus 3, Congenital, Autosomal Dominant

  • NYS3

  • Congenital Nystagmus 3

  • Autosomal Dominant Congenital Nystagmus 3
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Infertility
Spermatogenic Failure 9

  • Male Infertility Due To Globozoospermia

  • SPGF9

  • Male Infertility Due To Round-Headed Spermatozoa

  • Globozoospermia, Complete

  • Globozoospermia, Total

  • Globozoospermia

  • Globozoospermia Syndrome

  • Round-Headed Sperm Syndrome

  • Globozoospermia Complete

  • Globozoospermia Total
Prostate Carcinoma In Situ

  • Carcinoma In Situ Of Prostate

  • Grade Iii Pin

  • Pin Iii
Spermatogenic Failure 5

  • Male Infertility With Large-Headed, Multiflagellar, Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Dna

  • SPGF5

  • Macrocephalic Sperm Head Syndrome

  • Male Infertility Due To Macrozoospermia

  • Infertility Associated With Multitailed Spermatozoa And Excessive Dna

  • Macrozoospermia

  • Male Infertility Due To Large-Headed Multiflagellar Polyploid Spermatozoa

  • Infertility Associated With Multi-Tailed Spermatozoa And Excessive Deoxyribonucleic Acid

  • Large-Headed Multiflagellar Polyploid Spermatozoa

  • Male Infertility With Large-Headed Multiflagellar Polyploid Spermatozoa
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-175525 MS44 Degrader 99.81% Unkown
HY-120279A CFI-400437 Inhibitor / Unkown
HY-123610 BRD-7880 Inhibitor / Unkown
HY-160691 GW814408X Inhibitor / Unkown
HY-RS01273 AURKC Human Pre-designed siRNA Set A / Unkown
HY-RS01274 Aurkc Mouse Pre-designed siRNA Set A / Unkown
HY-RS01275 AURKC Rat Pre-designed siRNA Set A / Unkown
HY-119948 AKCI Modulator / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta AURKC VGNC VGNC:70051
Mus musculus AURKC MGD MGI:1321119
Felis catus AURKC VGNC VGNC:60045
Rattus norvegicus AURKC RGD RGD:1309573
Canis familiaris AURKC VGNC VGNC:38313
Others AURKC NCBI