1. Cell Cycle/DNA Damage
  2. Polo-like Kinase (PLK)
  3. CFI-400437

CFI-400437 

Cat. No.: HY-120279A
Handling Instructions

CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM).

For research use only. We do not sell to patients.

CFI-400437 Chemical Structure

CFI-400437 Chemical Structure

CAS No. : 1169211-37-3

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Description

CFI-400437 is an indolinone-derived, ATP-competitive kinase inhibitor with high selectivity for PLK4 (IC50 of 0.6 nM)[1].

In Vitro

CFI-400437 is a potent inhibitor of MCF-7, MDA-MB-468 and MDA-MB231 cell growth[1].
CFI-400437 inhibits Aurora A, Aurora B, KDR and FLT-3 with IC50s of 0.37, 0.21, 0.48, and 0.18 µM, respectively, i.e. two orders of magnitude higher than its IC50 of 0.6 nM against PLK4[1].
CFI-400437 inhibits both AURKB and AURKC at concentrations <15 nM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

CFI-400437 (25 mg/kg, ip, once daily for 21 d) exhibits antitumor activity against MDA-MB-468 breast cancer mouse xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

492.57

Formula

C₂₉H₂₈N₆O₂

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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CFI-400437
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