SULT2B1 - sulfotransferase family 2B member 1 Gene

Also Known as HSST2; ARCI14

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6820

About SULT2B1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,552,172-48,599,427 (from NCBI)

This gene has 4 transcripts (splice variants), 170 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in esophagus (RPKM 55.8), skin (RPKM 46.5) and 4 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene sulfates dehydroepiandrosterone but not 4-nitrophenol, a typical substrate for the phenol and estrogen sulfotransferase subfamilies. Two alternatively spliced variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

SULT2B1 Products (2)

mRNA	Protein	Name
NM_004605.2	NP_004596.2	sulfotransferase 2B1 isoform a
NM_177973.2	NP_814444.1	sulfotransferase 2B1 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables cholesterol binding	IDA IDA: Inferred from direct assay	12923182	GOA
enables nucleic acid binding	IMP IMP: Inferred from mutant phenotype	12923182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables small molecule binding	EXP EXP: Inferred from Experiment	12923182	GOA
enables steroid hormone binding	IMP IMP: Inferred from mutant phenotype	12923182	GOA
enables steroid sulfotransferase activity	IDA IDA: Inferred from direct assay	9799594	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	12923182	GOA
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in positive regulation of epidermal cell differentiation	IMP IMP: Inferred from mutant phenotype	28575648	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	9799594	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	28575648	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT2B1 Protein Structure

Sulfotransfer_1

0
100
200
300
365 a.a.

Protein Preferred Names	Protein Names
sulfotransferase 2B1	ST2B1

SULT2B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Bait-Prey Pool	25910212
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Array	32296183
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	25910212
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	25416956
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Array	25910212
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	25416956
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	SULT1B1	Homo sapiens	O43704	Validated Y2H	32296183
Intra	SULT2B1	O00204	ACYP2	Homo sapiens	P14621	Y2H Array	25416956
Intra	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Y2H Array	32296183
Intra	SULT2B1	O00204	ZNF497	Homo sapiens	Q6ZNH5	Validated Y2H	32296183
Intra	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Validated Y2H	32296183
Intra	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Y2H Array	32296183
Intra	SULT2B1	O00204	SRP72	Homo sapiens	O76094	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Validated Y2H	32296183
Intra	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	SULT2B1	O00204	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Bait-Prey Pool	25910212
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	25910212
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	25910212
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Validated Y2H	32296183
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35-2	Y2H Array	32296183
Intra	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Validated Y2H	32296183
Intra	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	KLHL8	Homo sapiens	Q9P2G9-2	Y2H Array	32296183
Intra	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Validated Y2H	32296183
Intra	SULT2B1	O00204	SULT1C3	Homo sapiens	Q6IMI6	Y2H Array	32296183
Intra	SULT2B1	O00204	PRICKLE3	Homo sapiens	O43900	Y2H Prey Pooling	25416956
Intra	SULT2B1	O00204	PRICKLE3	Homo sapiens	O43900	Y2H Array	25416956
Intra	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Validated Y2H	25910212
Intra	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Array	31515488
Intra	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Bait-Prey Pool	25910212
Intra	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Y2H Array	25910212
Intra	SULT2B1	O00204	SULT1A1	Homo sapiens	P50225	Validated Y2H	25416956
Intra	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	SULT2B1	O00204	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Pooling	16189514
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Array	25416956
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Prey Pooling	25416956
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Pooling	19060904
Intra	SULT2B1	O00204	FLACC1	Homo sapiens	Q96Q35	Y2H Array	19060904

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT2B1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76666	SULT2B1 Protein, Human (His)	O00204-1 (D2-S365)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Ichthyosis, Congenital, Autosomal Recessive 14	ARCI14 Autosomal Recessive Congenital Ichthyosis 14
Ichthyosis, Congenital, Autosomal Recessive 1	Collodion Fetus Autosomal Recessive Congenital Ichthyosis 1 ARCI1 Ichthyosis Congenita Lamellar Exfoliation Of Newborn Desquamation Of Newborn Ichthyosis Congenita Ii Shcb Icr2 Bathing Suit Ichthyosis Li1 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution Collodion Baby, Self-Healing Ichthyosis, Lamellar, 1, Formerly Li1, Formerly Ichthyosis Lamellar 1 Lamellar Ichthyosis, Type 1 Bsi Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution Autosomal Recessive Congenital Ichthyosis Tgm1-Related Lamellar Ichthyosis 1 Non-Erythrodermic Ichthyosis Ichthyosis, Congenital, Autosomal Recessive, Type 1 Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 2	Autosomal Recessive Congenital Ichthyosis 2 ARCI2 Ncie1 Ichthyosiform Erythroderma, Congenital Collodion Baby, Self-Healing Ichthyosiform Erythroderma, Nonbullous Congenital, 1, Formerly Ncie1, Formerly Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form, Formerly Brocq Congenital Ichthyosiform Erythroderma Nonbullous Form Nonbullous Congenital Ichthyosiform Erythroderma 1 Cie Ichthyosiform Erythroderma Brocq Congenital Non-Bullous Form Iecn1 Non-Bullous Congenital Ichthyosiform Erythroderma Type 1 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 2 Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Autosomal Recessive Congenital Ichthyosis	Lamellar Ichthyosis Congenital Ichthyosiform Erythroderma Li Congenital Nonbullous Ichthyosiform Erythroderma Arci Congenital Lamellar Ichthyosis Nonbullous Congenital Ichthyosiform Erythroderma Cie Congenital Non-Bullous Ichthyosiform Erythroderma Erythrodermic Ichthyosis Nbcie Ncie Non-Bullous Congenital Ichthyosiform Erythroderma Collodion Baby Ichthyosis, Lamellar Non Bullous Congenital Ichthyosiform Erythroderma Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form Ichthyosiform Erythroderma, Congenital, Nonbullous, 1 Collodion Baby Syndrome Ichthyoses, Lamellar Nbie Nonbullous Ichthyosiform Erythroderma Classic Lamellar Ichthyosis Ichthyosiform Erythroderma Nonbullous Congenital Ichthyosiform Erythroderma Congenital Ichthyosis, Congenital, Autosomal Recessive Ichthyosiform Erythroderma, Congenital Collodion Fetus Non-Bullous Ichthyosiform Erythroderma
Ichthyosis	Ichthyoses Non-Syndromic Ichthyosis Congenital Ichthyosis
Ichthyosis, Congenital, Autosomal Recessive 4b	Harlequin Ichthyosis Autosomal Recessive Congenital Ichthyosis 4b Hi Harlequin Fetus ARCI4B Ichthyosis Congenita, Harlequin Fetus Type Harlequin Type Ichthyosis 'Harlequin Fetus' Harlequin Type Ichthyosis Congenita Harlequin Type Ichthyosis Fetalis Harlequin Baby Syndrome Ichthyosis Congenita, Harlequin Type Ichthyosis Fetalis, Harlequin Type Ichthyosis Congenita Harlequin Fetus Type Ichthyosis, Harlequin Ichthyosis, Congenital, Autosomal Recessive, Type 4b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14021	SULT2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19554	Sult2b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26050	Sult2b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SULT2B1	VGNC	VGNC:65837
Rattus norvegicus	SULT2B1	RGD	RGD:1308882
Mus musculus	SULT2B1	MGD	MGI:1926342
Canis familiaris	SULT2B1	VGNC	VGNC:46979
Bos taurus	SULT2B1	VGNC	VGNC:35468
Others	SULT2B1	NCBI