PRDX2 - peroxiredoxin 2 Gene

Also Known as PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7001

About PRDX2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,796,823-12,801,800 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 201.9), heart (RPKM 194.1) and 25 other tissues.

Summary

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the Antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing Hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in Cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

PRDX2 Products (1)

mRNA	Protein	Name
NM_005809.6	NP_005800.3	peroxiredoxin-2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables antioxidant activity	IDA IDA: Inferred from direct assay	8144038	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17557078	GOA
enables thioredoxin peroxidase activity	IDA IDA: Inferred from direct assay	8144038	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to oxidative stress	IDA IDA: Inferred from direct assay	20978343	GOA
involved in defense response to tumor cell	IMP IMP: Inferred from mutant phenotype	30429596	GOA
involved in regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	12943237	GOA
involved in removal of superoxide radicals	IDA IDA: Inferred from direct assay	20978343	GOA
involved in response to oxidative stress	IMP IMP: Inferred from mutant phenotype	12943237	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRDX2 Protein Structure

AhpC-TSA

1-cysPrx_C

0
100
198 a.a.

Protein Preferred Names	Protein Names
peroxiredoxin-2	epididymis secretory sperm binding protein Li 2a

PRDX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PRDX2	P32119	STAT3	Homo sapiens	P40763	Pull Down	25402766
Intra	PRDX2	P32119	TXN	Homo sapiens	P10599	Pull Down	25402766

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PRDX2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71464	Peroxiredoxin-2/PRDX2 Protein, Human (His)	P32119-1 (A2-N198)	≥ 90%, as determined by reducing SDS-PAGE.
HY-P73374	Peroxiredoxin-2/PRDX2 Protein, Human (sf9, His)	P32119-1 (M1-N198)	≥ 90%, as determined by reducing SDS-PAGE.

PRDX2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81840	Peroxiredoxin 2 Antibody (YA1585)	WB, IHC-P	Human, Mouse, Rat
HY-P81840A	Peroxiredoxin 2 Antibody (YA1585)(PBS only)	WB, IHC-P	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hemolytic Anemia	Anemia, Hemolytic Anemia Hemolytic Anaemia Due To Other Disorders Of Glutathione Metabolism Chronic Non Spherocytic Anaemia G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia Favism Anaemia Haemolytic Anaemia Due Tog6pd Deficiency Favism Pentose Phosphate Pathway Disorder Anaemia Anaemia Due To Pentose Phosphate Pathway Defect
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1
Hereditary Spherocytosis	Congenital Spherocytic Hemolytic Anemia Spherocytic Anemia Congenital Spherocytosis Spherocytosis, Type 1 Minkowski Chauffard Syndrome Hs Minkowski-Chauffard Disease Minkowski-Chauffard Syndrome Spherocytosis Hereditary Spherocytosis, Hereditary Anemia, Hereditary Spherocytic Hemolytic
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1324	Oxiconazole nitrate		98.0%	Yes
HY-B1324A	Oxiconazole		/	Unkown

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11075	PRDX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17423	Prdx2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23878	Prdx2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PRDX2	MGD	MGI:109486
Rattus norvegicus	PRDX2	RGD	RGD:3838
Bos taurus	PRDX2	VGNC	VGNC:33300
Felis catus	PRDX2	VGNC	VGNC:69037
Canis familiaris	PRDX2	VGNC	VGNC:44951
Others	PRDX2	NCBI