ARTN - artemin Gene

Also Known as ART; EVN; NBN; ENOVIN

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 9048

About ARTN

Cytogenetic location: 1p34.1 Genomic coordinates (GRCh38): 1:43,933,801-43,937,240 (from NCBI)

This gene has 11 transcripts (splice variants), 214 orthologues and 3 paralogues. Broad expression in placenta (RPKM 1.0), prostate (RPKM 0.9) and 20 other tissues.

Summary

This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of Smad Family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

ARTN Products (3)

mRNA	Protein	Name
NM_001136215.2	NP_001129687.1	artemin isoform 3
NM_057090.3	NP_476431.2	artemin isoform 3
NM_057091.3	NP_476432.2	artemin isoform 1 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	31535977	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16765900	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glial cell-derived neurotrophic factor receptor signaling pathway	IDA IDA: Inferred from direct assay	31535977	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	15204970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARTN Protein Structure

TGF_beta

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
artemin	neublastin

ARTN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARTN	Q5T4W7	GFRA3	Homo sapiens	O60609	X-Ray Diffraction	16765900
Intra	ARTN	Q5T4W7	GFRA3	Homo sapiens	O60609	ITC	16765900
Intra	ARTN	Q5T4W7	GFRA3	Homo sapiens	O60609	GMS	16765900
Intra	ARTN	Q5T4W7	GFRA3	Homo sapiens	O60609	Light Scattering	16765900

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ARTN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7607	Artemin Protein, Human	Q5T4W7 (A108-G220)	≥ 95%, as determined by reducing SDS-PAGE.

ARTN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82410	Artemin Antibody (YA2155)	WB, IHC-P, IP	Human, Mouse, Rat
HY-P82410A	Artemin Antibody (YA2155)(PBS only)	WB, IHC-P, IP	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Burning Mouth Syndrome	Orodynia Stomatodynia Stomatopyrosis Bms Burning Mouth Disorder Oral Dysesthesia Sore Mouth Syndrome Bms - [Burning Mouth Syndrome]
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Multiple Endocrine Neoplasia, Type Iib	Multiple Endocrine Neoplasia Type 2b MEN2B Wagenmann-Froboese Syndrome Multiple Endocrine Neoplasia Iib Mucosal Neuroma Syndrome Multiple Endocrine Neoplasia, Type 3 Multiple Endocrine Neoplasia, Type 2b Men Iib Neuromata, Mucosal, With Endocrine Tumors Multiple Endocrine Neoplasia, Type Iii, Formerly Men3, Formerly Men Type Iib Men 2b Multiple Endocrine Neoplasia Type 3 Multiple Neoplasia 2b Neoplasia, Endocrine, Multiple, Type Iib
Megacolon	Dilatation Of Colon
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Congenital Central Hypoventilation Syndrome	Cchs Haddad Syndrome Ondine Curse Ondine Syndrome Congenital Central Hypoventilation Congenital Central Alveolar Hypoventilation Syndrome Congenital Failure Of Autonomic Control Ondine'S Curse Primary Alveolar Hypoventilation Ondine-Hirschsprung Disease Central Congenital Hypoventilation Syndrome Congenital Ondine Curse Idiopathic Congenital Central Alveolar Hypoventilation Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome Ondine-Hirschsprung Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01048	ARTN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19116	Artn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25606	Artn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ARTN	RGD	RGD:621427
Macaca mulatta	ARTN	VGNC	VGNC:70026
Mus musculus	ARTN	MGD	MGI:1333791
Bos taurus	ARTN	VGNC	VGNC:26181
Others	ARTN	NCBI