MINPP1 - multiple inositol-polyphosphate phosphatase 1 Gene

Homo sapiens

Also known as MIPP; PCH16; HIPER1; MINPP2

Gene ID: 9562 | Gene type: protein coding

About MINPP1

Cytogenetic location: 10q23.2 Genomic coordinates (GRCh38): 10:87,504,893-87,553,461 (from NCBI)

This gene has 4 transcripts (splice variants), 301 orthologues and is associated with 4 phenotypes. Ubiquitous expression in bone marrow (RPKM 5.4), adrenal (RPKM 4.7) and 25 other tissues.

Summary

This gene encodes multiple inositol polyphosphate phosphatase; an Enzyme that removes 3-phosphate from inositol phosphate substrates. It is the only Enzyme known to hydrolzye inositol pentakisphosphate and inositol hexakisphosphate. This Enzyme also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate; an activity formerly thought to be exclusive to 2,3-BPG synthase/2-phosphatase (BPGM) in the Rapoport-Luebering shunt of the glycolytic pathway.[provided by RefSeq, Sep 2009]

MINPP1 Products(3)

mRNA	Protein	Name
NM_001178117.2	NP_001171588.1	multiple inositol polyphosphate phosphatase 1 isoform 2 precursor
NM_001178118.2	NP_001171589.1	multiple inositol polyphosphate phosphatase 1 isoform 3
NM_004897.5	NP_004888.2	multiple inositol polyphosphate phosphatase 1 isoform 1 precursor

MINPP1 Protein Structure

His_Phos_2

0
100
200
300
400
487 a.a.

Protein Preferred Names

Protein Names

multiple inositol polyphosphate phosphatase 1

2,3-BPG phosphatase

Recombinant MINPP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70937	MINPP1 Protein, Human (HEK293, His)	Q9UNW1 (S31-L487)	≥95%
HY-P71854	MINPP1 Protein, Human (P.pastoris, His)	Q9UNW1 (31S-487L)	≥95%

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 16

PCH16	Pontocerebellar Hypoplasia Type 16
Pontocerebellar Hypoplasia 16	Doid:0112333

Thyroid Cancer, Nonmedullary, 2

Thyroid Carcinoma, Follicular	Follicular Thyroid Carcinoma
NMTC2	Thyroid Cancer, Follicular
Thyroid Carcinoma, Follicular, Somatic	Ftc
Thyroid Cancer, Non-Medullary, 2	Thyroid Follicular Carcinoma
Follicular Thyroid Cancer	Cancer, Thyroid, Nonmedullary, Type 2
Thyroid Gland Adenocarcinoma	Follicular Carcinoma Of Unspecified Site
Moderately Differentiated Follicular Carcinoma Of Thyroid Gland	Pure Follicle Carcinoma Of Thyroid Gland
Pure Follicle Follicular Carcinoma Of Unspecified Site	Pure Follicular Carcinoma Of Thyroid Gland
Trabecular Follicular Carcinoma Of Thyroid Gland	Trabecular Follicular Carcinoma Of Unspecified Site
Well Differentiated Follicular Carcinoma Of Unspecified Site	Well Differentiated Follicular Carcinoma Of Thyroid Gland

Pontocerebellar Hypoplasia, Type 7

Pontocerebellar Hypoplasia Type 7	PCH7
Pontocerebellar Hypoplasia-46,Xy Disorder Of Sex Development Syndrome	Pontocerebellar Hypoplasia 7
Hypoplasia, Pontocerebellar, Type 7

Non-Syndromic Pontocerebellar Hypoplasia

Pontoneocerebellar Hypoplasia	Pch
Pontoneocerebellar Atrophy

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Familial Papillary Or Follicular Thyroid Carcinoma

Fnmtc	Familial Pure Nonmedullary Thyroid Carcinoma
Familial Nonmedullary Thyroid Gland Carcinoma

Lipoid Proteinosis Of Urbach And Wiethe

Lipoid Proteinosis	Urbach-Wiethe Disease
Hyalinosis Cutis Et Mucosae	Lipid Proteinosis
Lipoproteinosis	Urbach Wiethe Disease
Lipoglycoproteinosis	Lipoidosis Cutis Et Mucosae
Lipoidproteinosis	Urbach-Wiethe Lipoid Proteinosis
Urbach-Wiethe Syndrome	LIP
Proteinosis Lipoid

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08457	MINPP1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MINPP1	VGNC	VGNC:74871
Canis familiaris	MINPP1	VGNC	VGNC:59061
Bos taurus	MINPP1	VGNC	VGNC:31480
Mus musculus	MINPP1	MGD	MGI:1336159
Rattus norvegicus	MINPP1	RGD	RGD:3089
Others	MINPP1	NCBI

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