GLP-1R-agonist-43
GLP-1R-agonist-43 (Compound A) is an orally active GLP-1R agonist with an EC50 of 2.68 nM. GLP-1R-agonist-43 can be used in the research of non-insulin-dependent diabetes mellitus (type 2 diabetes) and obesity.
For research use only. We do not sell to patients.
- CAS No.: 3092659-72-5
- Formula: C54H56FN9O6
- Molecular Weight:946.08
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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GLP-1R 2.68 nM (EC50) |
GLP-1R-agonist-43 (starting at a concentration of 10 μM with 3-fold serial dilution) potently activates the glucagon-like peptide-1 receptor in cAMP Hunter™ CHO-K1 GLP1R Gs cells, with an EC50 of 2.68 nM and a maximum efficacy of 74.8% relative to GLP-1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| Species | Dose | Route | T1/2 | AUC0-t | Bioavailability |
|---|---|---|---|---|---|
| Monkey[1] | 1.5 mg/kg | p.o. | 12 h | 3495 ng·h/mL | 39 % |
Chemical Information
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CAS No. 3092659-72-5
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Molecular Weight 946.08
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Formula C54H56FN9O6
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SMILES
O=C(C1=CC(C=C([C@@H]2CC(C)(C)OCC2)C=C3)=C3N1[C@]4(C[C@@H]4C)C(NO5)=NC5=O)N6CC7(CC7)C8=NN(C9=CC(C)=C(F)C(C)=C9)C(N%10C=CN(C%11=CC=C(C%12(CCC%12)C(N%13C)=O)C%13=C%11)C%10=O)=C8[C@@H]6C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GLP-1R-agonist-43 Related Classifications
HY-182502 Related Classifications
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