Glucocorticoid receptor/IL-6-IN-2
Glucocorticoid receptor/IL-6-IN-2 (Compound 36) is a selective dual inhibitor targeting the glucocorticoid receptor (GR) and IL-6 signaling pathway (IC50 values of 40 nM and 19 nM, respectively). Glucocorticoid receptor/IL-6-IN-2 is promising for research of inflammatory diseases like rheumatoid arthritis and asthma.
For research use only. We do not sell to patients.
- CAS No.: 1198784-83-6
- Formula: C22H23ClF3N3O4S
- Molecular Weight:517.95
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
IL-6 59 nM (IC50) |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HFF | IC50 |
19 nM
Compound: 36
|
Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production
Agonist activity at GR in HFF cells assessed as suppression of IL-1-induced IL-6 production
|
[PMID: 25516791] |
Chemical Information
-
CAS No. 1198784-83-6
-
Molecular Weight 517.95
-
Formula C22H23ClF3N3O4S
-
SMILES
O=C(C1=CC(Cl)=CC=C1C(C)(CC(CC2=CC3=C(N2)C=NC(S(=O)(C)=O)=C3)(C(F)(F)F)O)C)N
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Glucocorticoid receptor/IL-6-IN-2 Related Classifications
HY-176877 Related Classifications
Powered by Bioz