GPR3 agonist-2

製品番号: HY-155318A 純度: 99.90%: Data Sheet SDS COA 取扱説明書
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GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC₅₀of 260 nM.

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GPR3 agonist-2 構造式

CAS 番号 : 1983120-51-9

容量	価格（税別）	在庫状況	数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 169	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 169	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$150	在庫あり	Estimated Time of Arrival: December 31
10 mg	$240	在庫あり	Estimated Time of Arrival: December 31
25 mg	$460	在庫あり	Estimated Time of Arrival: December 31
50 mg	$730	在庫あり	Estimated Time of Arrival: December 31
100 mg	$1100	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

GPR3 agonist-2(compound 32) is a potent full agonist of G protein-coupled receptor 3, with the IC₅₀of 260 nM^[1].

分子量

512.16

分子式

C₁₄H₇F₆IO₄S

CAS 番号

1983120-51-9

Appearance

Solid

Color

Off-white to yellow

SMILES

FC(F)(F)OC1=CC=C(C([I+]2)=C1)C3=C2C=CC=C3.[O-]S(=O)(C(F)(F)F)=O

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶剤 & 溶解度

体外:

DMSO : 100 mg/mL (195.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.9525 mL	9.7626 mL	19.5252 mL
5 mM	0.3905 mL	1.9525 mL	3.9050 mL
10 mM	0.1953 mL	0.9763 mL	1.9525 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.88 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.90%

Select Batch:

データシート (267 KB) SDS (252 KB)

COA (246 KB) HNMR (205 KB) CNMR (116 KB) RP-HPLC (256 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Gay EA, et al. The development of diphenyleneiodonium analogs as GPR3 agonists. Bioorg Med Chem Lett. 2023;94:129427. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.9525 mL	9.7626 mL	19.5251 mL	48.8129 mL
	5 mM	0.3905 mL	1.9525 mL	3.9050 mL	9.7626 mL
	10 mM	0.1953 mL	0.9763 mL	1.9525 mL	4.8813 mL
	15 mM	0.1302 mL	0.6508 mL	1.3017 mL	3.2542 mL
	20 mM	0.0976 mL	0.4881 mL	0.9763 mL	2.4406 mL
	25 mM	0.0781 mL	0.3905 mL	0.7810 mL	1.9525 mL
	30 mM	0.0651 mL	0.3254 mL	0.6508 mL	1.6271 mL
	40 mM	0.0488 mL	0.2441 mL	0.4881 mL	1.2203 mL
	50 mM	0.0391 mL	0.1953 mL	0.3905 mL	0.9763 mL
	60 mM	0.0325 mL	0.1627 mL	0.3254 mL	0.8135 mL
	80 mM	0.0244 mL	0.1220 mL	0.2441 mL	0.6102 mL
	100 mM	0.0195 mL	0.0976 mL	0.1953 mL	0.4881 mL

GPR3 agonist-2 Related Classifications

Endocrinology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR3 agonist-21983120-51-9Orphan GPCRRrphan G protein-coupled receptordrug abuseneuropathic painanxiety,depression related disordersInhibitorinhibitorinhibit

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