GSPT1 degrader-12
GSPT1 degrader-12 is a selective molecular glue GSPT1 degrader. GSPT1 degrader-12 exhibits antiproliferative activity against cancer cells in a CRBN- and GSPT1-dependent manner. GSPT1 degrader-12 can be used for leukemia research.
For research use only. We do not sell to patients.
- Formula: C26H32N4O6S
- Molecular Weight:528.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
GSPT1 degrader-12 (compound 2) (3 days) exhibits anti-proliferative activity against cancer cells, with EC50s of 0.06 (MOLT4), 0.04 (MV4;11), and 13 μM (BE(2)-C)[1].
GSPT1 degrader-12 (3 h) shows GSPT1 degradation activity in MOLT4, MV4;11, and BE(2)-C cells, with DC50s of 0.09, 0.12, and 14 μM, respectively[1].
GSPT1 degrader-12 (3 μM, 3 h) degrades GSPT1 in wild-type MOLT4, MV4;11, and BE(2)-C cells, but its degradation activity is blocked by CRBN KO cells and G575N mutant cells, indicating that it degrades GSPT1 in a CRBN- and GSPT1-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 528.62
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Formula C26H32N4O6S
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SMILES
CC(CCOC1=CC=CC=C1CCNS(=O)(NC2=CC=C3C(N(CC3=C2)C4CCC(NC4=O)=O)=O)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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