GSPT1 degrader-12 

GSPT1 degrader-12 is a selective molecular glue GSPT1 degrader. GSPT1 degrader-12 exhibits antiproliferative activity against cancer cells in a CRBN- and GSPT1-dependent manner. GSPT1 degrader-12 can be used for leukemia research^[1].

GSPT1 degrader-12 (compound 2) (3 days) exhibits anti-proliferative activity against cancer cells, with EC₅₀s of 0.06 (MOLT4), 0.04 (MV4;11), and 13 μM (BE(2)-C)^[1].
GSPT1 degrader-12 (3 h) shows GSPT1 degradation activity in MOLT4, MV4;11, and BE(2)-C cells, with DC₅₀s of 0.09, 0.12, and 14 μM, respectively^[1].
GSPT1 degrader-12 (3 μM, 3 h) degrades GSPT1 in wild-type MOLT4, MV4;11, and BE(2)-C cells, but its degradation activity is blocked by CRBN KO cells and G575N mutant cells, indicating that it degrades GSPT1 in a CRBN- and GSPT1-dependent manner^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

528.62

C₂₆H₃₂N₄O₆S

CC(CCOC1=CC=CC=C1CCNS(=O)(NC2=CC=C3C(N(CC3=C2)C4CCC(NC4=O)=O)=O)=O)C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Carter TR, et al. SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues. Bioorg Med Chem. 2024 Apr 15;104:117699.  [Content Brief]