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製品番号: HY-183888

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H3B-616

H3B-616 is a selective carbamoyl phosphate synthetase 1 (CPS1) inhibitor with a human IC₅₀ of 66 nM. H3B-616 binds to an allosteric pocket in the CPS1 integrating domain to exert target engagement and inhibit enzyme activity. H3B-616 can be used for the research of nonsmall cell lung cancer and gastric cancer.

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CAS 番号: 2468199-06-4
分子式: C₂₃H₂₄FN₃O₃
分子量:409.45

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

H3B-616 構造式

CAS 番号: 2468199-06-4

容量

価格（税別）

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数量

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

IC₅₀ & Target^[1]

CPS I

66 nM (IC₅₀)

Carbamoyl Phosphate Synthetase (CPS) アイソフォーム固有の製品をすべて表示 :

CPS I

Cellular Effect

Cell Line	Type	Value	Description	References
Sf21	IC₅₀	0.066 μM Compound: 25; H3B-616	Allosteric inhibition of His-tagged CPS1 (unknown origin) expressed in baculovirus infected Sf21 insect cells assessed as reduction in ADP level preincubated for 20 mins followed by ATP addition measured after 60 mins by ADP-Glo assay Allosteric inhibition of His-tagged CPS1 (unknown origin) expressed in baculovirus infected Sf21 insect cells assessed as reduction in ADP level preincubated for 20 mins followed by ATP addition measured after 60 mins by ADP-Glo assay	[PMID: 32551016]

体外実験

H3B-616 (Compound 25) potently inhibits purified human CPS1 enzyme activity with an IC₅₀ of 66 nM^[1].
H3B-616 does not appreciably inhibit purified human CPS2 enzyme activity, with an IC₅₀ of ≥100 μM^[1].
H3B-616 (0.01-100 μM; 16 h) potently inhibits CPS1 activity (urea production) in primary human hepatocytes with an IC₅₀ of 0.24 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 2468199-06-4
分子量 409.45
分子式 C₂₃H₂₄FN₃O₃
SMILES

O=C(N1C[C@H](N([C@@H](C1)C)C(C2=C(C=C(C=C2)OC)F)=O)C)C3=CC=C(C=CN4)C4=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Rolfe A, et al. Discovery of 2,6-Dimethylpiperazines as Allosteric Inhibitors of CPS1. ACS Med Chem Lett. 2020;11(6):1305-1309. Published 2020 May 26. [Content Brief]

[2]. Gavande NS, et al. Structure-Guided Optimization of Replication Protein A (RPA)-DNA Interaction Inhibitors. ACS Med Chem Lett. 2020;11(6):1118-1124. Published 2020 Jan 2. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

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H3B-616

Carbamoyl Phosphate Synthetase (CPS) アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

H3B-616 関連分類

HY-183888 関連分類