I-bu-rG Phosphoramidite
Based on 1 Customer Validation
I-bu-rG Phosphoramidite is a phosphoramidite monomer that can be used in the synthesis of nucleotides and nucleic acids.
For research use only. We do not sell to patients.
- Purity: 98.0%
- CAS No.: 147201-04-5
- Formula: C50H68N7O9PSi
- Molecular Weight:970.18
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
I-bu-rG Phosphoramidite serves as a precursor to synthesize (2R,3R,4R,5R)-4--2-(hydroxymethyl)-5-(2-isobutyramido-6-oxo-1,6-dihydro-9H-purin-9-yl)tetrahydrofuran-3-yl hydrogen phosphonate[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 147201-04-5
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Appearance Solid
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Molecular Weight 970.18
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Formula C50H68N7O9PSi
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Color White to yellow
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SMILES
COC(C=C1)=CC=C1C(C2=CC=CC=C2)(C3=CC=C(OC)C=C3)OC[C@@H]4[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](N5C(N=C(NC(C(C)C)=O)NC6=O)=C6N=C5)O4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (103.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (277 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0307 mL | 5.1537 mL | 10.3074 mL | 25.7684 mL |
| 5 mM | 0.2061 mL | 1.0307 mL | 2.0615 mL | 5.1537 mL | |
| 10 mM | 0.1031 mL | 0.5154 mL | 1.0307 mL | 2.5768 mL | |
| 15 mM | 0.0687 mL | 0.3436 mL | 0.6872 mL | 1.7179 mL | |
| 20 mM | 0.0515 mL | 0.2577 mL | 0.5154 mL | 1.2884 mL | |
| 25 mM | 0.0412 mL | 0.2061 mL | 0.4123 mL | 1.0307 mL | |
| 30 mM | 0.0344 mL | 0.1718 mL | 0.3436 mL | 0.8589 mL | |
| 40 mM | 0.0258 mL | 0.1288 mL | 0.2577 mL | 0.6442 mL | |
| 50 mM | 0.0206 mL | 0.1031 mL | 0.2061 mL | 0.5154 mL | |
| 60 mM | 0.0172 mL | 0.0859 mL | 0.1718 mL | 0.4295 mL | |
| 80 mM | 0.0129 mL | 0.0644 mL | 0.1288 mL | 0.3221 mL | |
| 100 mM | 0.0103 mL | 0.0515 mL | 0.1031 mL | 0.2577 mL |
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