SW208108
SW208108 is a prodrug of dMe-SW208108, a CYP4F11-activated SCD inhibitor, with an IC50 value of 9 nM. SW208108 undergoes demethylation by CYP4F11 to form the active metabolite dMe-SW208108, thereby inhibiting enzyme function. SW208108 depletes unsaturated fatty acids, induces cytotoxicity in non-small cell lung cancer (NSCLC) cells expressing CYP4F11, and does not affect SCD activity in mouse sebocytes. SW208108 can be used in studies related to NSCLC.
For research use only. We do not sell to patients.
- CAS No.: 1673557-43-1
- Formula: C27H24N2O5
- Molecular Weight:456.50
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
SW208108 selectively reduces the viability of four NSCLC cell lines (H2122, H460, HCC44, HCC4017) with an IC50 of 0.014-0.031 μM; it exhibits moderate toxicity against H2073 cells, but shows no toxicity against another seven NSCLC cell lines[1].
SW208108 is selectively metabolized to dMe-SW208108 in H2122 non-small cell lung cancer cells, whereas it remains unmetabolized in H1155 non-small cell lung cancer cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 1673557-43-1
-
Molecular Weight 456.50
-
Formula C27H24N2O5
-
SMILES
O=C(NC1=CC=C(C=C1)C(=O)C2=CC=C(OCC#C)C=C2)C(=O)NCCC3=CC=C(OC)C=C3
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SW208108 Related Classifications
HY-114606 Related Classifications
Powered by Bioz