IHVR-17028

Cat. No.: HY-139663 Pureza: 99.61%: Ficha de datos
COA

SDS
Instrucciones de manejo
FAQs
Technical Support

IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

Para uso exclusivo en investigación. No vendemos a pacientes.

IHVR-17028 Estructura química

No. CAS : 1428247-78-2

Tamaño	Stock	Cantidad
1 mg	En stock	Estimated Time of Arrival: December 31
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

or Consulta para venta a granel

* Seleccione Cantidad antes de agregar artículos.

This product is a controlled substance and not for sale in your territory.

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica
Pureza y Documentación
Referencias
Revisión del cliente

Descripciòn

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	500 μM Compound: 24	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23453839]
Huh-7	CC₅₀	500 μM Compound: 3	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 3	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 24	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells Antiviral activity against Tacaribe virus infected in human Huh7.5 cells	[PMID: 23453839]

In Vitro

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC₅₀ values of all >500 μM in?MDBK, Huh7.5 or BHK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a C_max?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T_1/2 value is 0.88 hour after iv. adminstration^[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection^[1]
Dosage:	50 mg/kg
Administration:	Treatment 1 day prior to virus challenging
Result:	Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.

Animal Model:	C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV^[1]
Dosage:	25 mg/kg
Administration:	Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result:	Inhibited EBOV infection in mice.

Peso molecular

428.61

Fòrmula

C₂₃H₄₄N₂O₅

No. CAS

1428247-78-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Pureza y Documentación

Purity: 99.61%

Select Batch:

Ficha de datos (272 KB) SDS (252 KB)

COA (247 KB) HNMR (163 KB) RP-HPLC (250 KB) LCMS (109 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40. [Content Brief]

IHVR-17028 Related Classifications

Infection

Calculadora de molaridad
Calculadora de dilución

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IHVR-170281428247-78-2IHVR17028IHVR 17028Glycosidaseviraltacaribe virusDENVBVDVdiarrhea virusMDBKHuh7.5BHKInhibitorinhibitorinhibit

Productos vistos recientemente:

Nombre del producto

Requested Quantity *

Nombre del solicitante *

Saludo

Direcciòn del E-mail *

Número de teléfono *

Department

Nombre de la Organizaciòn *

City

Provincia

Country or Region *

Observaciones

Nombre del producto

Lot #

Nombre del solicitante *

Direcciòn del E-mail *

Número de teléfono

Department *