IHVR-17028

製品番号: HY-139663 純度: 99.61%: Data Sheet SDS COA 取扱説明書
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IHVR-17028 is a potent and broad-spectrum antiviral agent. IHVR-17028 exhibits antiviral activity against BVDV, TCRV and DENV with EC₅₀ values of 0.4 μM, 0.26 μM, 0.3 μM, respectively. IHVR-17028 is a potent ER α-glucosidase I inhibitor with an IC₅₀ of 0.24 μM. IHVR-17028 can be used for infectious diseases research.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

IHVR-17028 構造式

CAS 番号 : 1428247-78-2

容量	価格（税別）	在庫状況	数量
1 mg	$360	在庫あり	Estimated Time of Arrival: December 31
5 mg	$830	在庫あり	Estimated Time of Arrival: December 31
10 mg	$1150	在庫あり	Estimated Time of Arrival: December 31
25 mg	$1760	在庫あり	Estimated Time of Arrival: December 31
50 mg	$2200	在庫あり	Estimated Time of Arrival: December 31
100 mg	$2750	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

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* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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純度とドキュメンテーション
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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	500 μM Compound: 24	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23453839]
Huh-7	CC₅₀	500 μM Compound: 3	Cytotoxicity against human Huh7.5 cells by MTT assay Cytotoxicity against human Huh7.5 cells by MTT assay	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 3	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis Antiviral activity against Tacaribe virus infected in human Huh7.5 cells assessed as reduction in viral yield after 3 days by neutral-red staining-based microscopic analysis	[PMID: 23747225]
Huh-7	EC₅₀	0.2 μM Compound: 24	Antiviral activity against Tacaribe virus infected in human Huh7.5 cells Antiviral activity against Tacaribe virus infected in human Huh7.5 cells	[PMID: 23453839]

体外実験

In virus yield reduction assays, IHVR-17028 inhibits viral activities with EC50 values of 0.4 μM, 0.26 μM, 0.3 μM for bovine viral diarrhea virus (BVDV) (NADL strain), tacaribe virus (TCRV) (11573 strain), DENV (serotype 2, New Guinea C), respectively. And in MTT assays, IHVR-17028 exhibits IC₅₀ values of all >500 μM in?MDBK, Huh7.5 or BHK cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

In Pharmacokinetic analysis in rats, IHVR17028 (oral gavage; 75 mg/kg) shows a C_max?value of 0.18 μg/ml; the Tmax value is 1.56 hours; and the F% value is 12% after PO administration, the T_1/2 value is 0.88 hour after iv. adminstration^[1].
IHVR-17028 (oral gavage; 25-50 mg/kg; treatment 1 day prior to virus challenging) exhibits significant protection in mouse model of lethal MARV infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	BALB/c mice are challenged with 1,000 PFU mouse adapted MARV via IP injection^[1]
Dosage:	50 mg/kg
Administration:	Treatment 1 day prior to virus challenging
Result:	Exhibited protection in mouse when the treatment is initiated 1 day prior to virus challenging.

Animal Model:	C57B1/6 mice challenged with 1,000 PFU mouse adapted EBOV^[1]
Dosage:	25 mg/kg
Administration:	Twice daily at 12 h interval; starting 4 h post infection for 10 days
Result:	Inhibited EBOV infection in mice.

分子量

428.61

分子式

C₂₃H₄₄N₂O₅

CAS 番号

1428247-78-2

Appearance

Oil

Color

Colorless to light yellow

SMILES

OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCCCN(C(C(C)(C)C)=O)C2CCCCC2

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

純度とドキュメンテーション

純度: 99.61%

Select Batch:

データシート (272 KB) SDS (252 KB)

COA (247 KB) HNMR (163 KB) RP-HPLC (250 KB) LCMS (109 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Jinhong Chang, et al. Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.Antiviral Res. 2013 Jun;98(3):432-40. [Content Brief]

IHVR-17028 Related Classifications

Infection

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IHVR-170281428247-78-2IHVR17028IHVR 17028Glycosidaseviraltacaribe virusDENVBVDVdiarrhea virusMDBKHuh7.5BHKInhibitorinhibitorinhibit

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