Isosorbide dimethyl ether
Based on 1 Customer Validation
Isosorbide dimethyl ether (Dimethyl isosorbide) is a bio-based green solvent. Isosorbide dimethyl ether is used for the preparation of sustainable ultrafiltration and microfiltration membranes. Isosorbide dimethyl ether can serve as an eco-friendly eluent for liquid chromatography. When used as a liquid chromatography mobile phase at a ratio of 50% (v/v) under 40 °C, with a system back pressure of 160-300 bar and an ultraviolet cutoff wavelength of 240 nm, Isosorbide dimethyl ether enables the quantitative analysis of Methylparaben (HY-W016806) and Propylparaben (HY-N2026) in biological preparations.
For research use only. We do not sell to patients.
- Purity: 99.64%
- CAS No.: 5306-85-4
- Formula: C8H14O4
- Molecular Weight:174.19
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Storage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Isosorbide dimethyl ether serves as an excellent solvent for PES, as well as PVDF Solef 6012 and 6010[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 5306-85-4
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Appearance Liquid (Density: 1.15 g/cm3)
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Molecular Weight 174.19
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Formula C8H14O4
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Color Colorless to light yellow
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SMILES
[H][C@]1(OC[C@@H]2OC)[C@]2([H])OC[C@H]1OC
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Synonyms
Dimethyl isosorbide; O,O-Dimethylisosorbide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : ≥ 100 mg/mL (574.09 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2016 May 25;87:88-99. [Content Brief]
[3]. Damjanoska A, et al. Dimethyl Isosorbide: An Innovative Bio-Renewable Solvent for Sustainable Chromatographic Applications. Molecules (Basel, Switzerland). 2025 Jun 24;30(13):2713. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.7409 mL | 28.7043 mL | 57.4086 mL | 143.5214 mL |
| 5 mM | 1.1482 mL | 5.7409 mL | 11.4817 mL | 28.7043 mL | |
| 10 mM | 0.5741 mL | 2.8704 mL | 5.7409 mL | 14.3521 mL | |
| 15 mM | 0.3827 mL | 1.9136 mL | 3.8272 mL | 9.5681 mL | |
| 20 mM | 0.2870 mL | 1.4352 mL | 2.8704 mL | 7.1761 mL | |
| 25 mM | 0.2296 mL | 1.1482 mL | 2.2963 mL | 5.7409 mL | |
| 30 mM | 0.1914 mL | 0.9568 mL | 1.9136 mL | 4.7840 mL | |
| 40 mM | 0.1435 mL | 0.7176 mL | 1.4352 mL | 3.5880 mL | |
| 50 mM | 0.1148 mL | 0.5741 mL | 1.1482 mL | 2.8704 mL | |
| 60 mM | 0.0957 mL | 0.4784 mL | 0.9568 mL | 2.3920 mL | |
| 80 mM | 0.0718 mL | 0.3588 mL | 0.7176 mL | 1.7940 mL | |
| 100 mM | 0.0574 mL | 0.2870 mL | 0.5741 mL | 1.4352 mL |
Isosorbide dimethyl ether Related Classifications
HY-134524 Related Classifications
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