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Cat. No.: HY-17627S1

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Avacopan-d₄

Name: Avacopan-d4
Brand: MedChemExpress
SKU: HY-17627S1
Availability: PreOrder

(Synonyms: CCX168-d₄)

Avacopan-d₄ (CCX168-d₄) is the deuterium labeled Avacopan (HY-17627). Avacopan (CCX168) is a potent, selective and orally available complement 5a receptor (C5aR) inhibitor with an IC₅₀ of 0.1 nM.

For research use only. We do not sell to patients.

CAS No.: 2316781-85-6
Formula: C₃₃H₃₁D₄F₄N₃O₂
Molecular Weight:585.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Avacopan-d₄ Chemical Structure

CAS No.: 2316781-85-6

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Protocols (1)
Purity & Documentation
Calculators
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Bioz

Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS No. 2316781-85-6
Unlabeled CAS 1346623-17-3
Molecular Weight 585.67
Formula C₃₃H₃₁D₄F₄N₃O₂
SMILES

O=C([C@@H]1[C@H](C2=CC=C(NC3CC([2H])([2H])C([2H])([2H])C3)C=C2)N(C(C4=C(C)C=CC=C4F)=O)CCC1)NC5=CC=C(C)C(C(F)(F)F)=C5
Synonyms

CCX168-d₄
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Handling Instructions (2659 KB)

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Protocols
Purity & Documentation

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Avacopan-d4