Efruxifermin
Based on 2 publication(s) in Google Scholar
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis.
For research use only. We do not sell to patients.
- Purity : 98.58%
- CAS No.: 2375240-92-7
- Molecular Weight:91.863 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Efruxifermin
More
Customer Validation & Images
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In Vivo Efficacy Study
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Histological Imaging/Staining
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RT-PCR
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WB
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IF
Biological Activity
Description
Species Reactivity
Human
IC50 & Target
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FGFR1 |
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male and female Sprague Dawley rats[1]
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Dosage:0, 1, 10, 30, 100 mg/kg
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Administration:Subcutaneous injection, Once weekly, for 4 or 26 weeks
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Result:Significantly reduced body weight gain after 4 and 26 weeks, despite increasing food intake. Markers of sympathetic activation, urinary corticosterone and ratio of adrenal-to-body weight were unchanged.
Clinical Trial
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IGHG1 Fc (Fragment constant)-[FGF21 (fibroblast growth factor 21)]2
Verified Bioactivity
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Loaded Efruxifermin on Protein A Chip, can bind Klotho beta Protein, Human (HEK293, His, HY-P77972) with an affinity constant of 2.21E-08 M as determined in SPR assay.
Chemical Information
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CAS No. 2375240-92-7
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Appearance Liquid
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Molecular Weight 91.863 kDa
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Color Colorless to light yellow
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SMILES
[Efruxifermin]
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Synonyms
AKR-001; AMG-876
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (2)
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Journal Impact Factor
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Most Recent
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J Adv Res
FGF21-FGFR1 signaling protects against cardiac hypertrophy by regulating PINK1-mediated mitophagy pathway. [Abstract]2025 Oct 29:S2090-1232(25)00848-3. PMID: 41173187
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Measurement of LVEF in the indicated groups.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). Representative image of HE staining.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP mRNA levels in the indicated group.
Efruxifermin purchased from MedChemExpress. Usage Cited in: J Adv Res. 2025 Oct 29:S2090-1232(25)00848-3. [Abstract]
Efruxifermin (FGF21; 1 mg/kg; subcutaneous injection). ANP and BNP protein levels in the indicated group.
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Research (Wash D C)
Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation. [Abstract]2025 Aug 5:8:0815. PMID: 40765997
Efruxifermin purchased from MedChemExpress. Usage Cited in: Research (Wash D C). 2025 Aug 5:8:0815. [Abstract]
Efruxifermin (5 mg/kg; subcutaneous injection). The expression of SMA and OPN in SMA-positive cells in neointimal areas was determined by immunofluorescence staining.
Protocols
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Protocol for Pharmacokinetic Study
Pharmacokinetic studies quantify how an organism handles a drug over time through absorption, distribution, metabolism, and excretion, and the core experimental readout is the concentration-time profile of parent drug and, when relevant, metabolites in biological matrices such as plasma, whole blood, urine, bile, or tissue. Pharmacokinetic analysis links dose, route, exposure, clearance, half-life, distribution, bioavailability, and systemic exposure to drug efficacy and toxicity hypotheses rather than measuring a signaling pathway directly. The literature links pharmacokinetics to drug-development phenotypes by showing that drug metabolism and pharmacokinetics influence compound progression, exposure-response interpretation, safety margins, dosing strategy, and failure risk during discovery and development. DMPK science contributes to compound optimization by integrating physicochemical properties, in vitro metabolism, transporter behavior, in vivo exposure, and pharmacodynamic contex
Purity & Documentation
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Data Sheet (260 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Efruxifermin Related Classifications
HY-P99930 Related Classifications
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