RPP14 - ribonuclease P/MRP subunit p14 Gene

Also Known as P14

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11102

About RPP14

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:58,306,245-58,320,193 (from NCBI)

This gene has 6 transcripts (splice variants) and 183 orthologues. Ubiquitous expression in thyroid (RPKM 4.8), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a subunit of ribonuclease P and has 3' to 5' exoribonuclease activity. Transcripts for this gene are bicistronic and include a conserved downstream open reading frame for the hydroxyacyl-thioester dehydratase type 2 (HTD2) gene. [provided by RefSeq, May 2017]

RPP14 Products (2)

mRNA Protein Name
NM_001098783.3 NP_001092253.1 ribonuclease P protein subunit p14
NM_007042.6 NP_008973.1 ribonuclease P protein subunit p14

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15096576 GOA
enables ribonuclease P RNA binding IDA
IDA: Inferred from direct assay
16723659 GOA
contributes to ribonuclease P activity IDA
IDA: Inferred from direct assay
30454648 GOA
Biological Process GO Annotation Evidence References Source
involved in tRNA 5'-leader removal IDA
IDA: Inferred from direct assay
16723659 GOA
Cellular Component GO Annotation Evidence References Source
part of multimeric ribonuclease P complex IDA
IDA: Inferred from direct assay
16723659 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
10444065 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPP14 Protein Structure

RNase_P_Rpp14

RNase_P_Rpp14: Rpp14/Pop5 family (23 - 109)

  • 0
  • 100
  • 124 a.a.
Protein Preferred Names Protein Names

ribonuclease P protein subunit p14

  • ribonuclease P/MRP 14kDa subunit

RPP14 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPP14 O95059 ZNF277 Homo sapiens G5E9M4
Y2H Prey Pooling
32296183
Intra
RPP14 O95059 ZNF277 Homo sapiens G5E9M4
Y2H Array
32296183
Intra
RPP14 O95059 POP4 Homo sapiens O95707
Anti Tag CoIP
33961781
Intra
RPP14 O95059 POP4 Homo sapiens O95707
Pull Down
15096576
Intra
RPP14 O95059 RPP40 Homo sapiens O75818
Anti Tag CoIP
33961781
Intra
RPP14 O95059 POP5 Homo sapiens Q969H6
Pull Down
15096576
Intra
RPP14 O95059 POP5 Homo sapiens Q969H6
Anti Tag CoIP
33961781
Intra
RPP14 O95059 RPP30 Homo sapiens P78346
Validated Y2H
32296183
Intra
RPP14 O95059 RPP30 Homo sapiens P78346
Y2H Array
32296183
Intra
RPP14 O95059 RPP30 Homo sapiens P78346
Anti Tag CoIP
33961781
Intra
RPP14 O95059 RPP30 Homo sapiens P78346
Y2H Prey Pooling
32296183
Intra
RPP14 O95059 RPP25 Homo sapiens Q9BUL9
Anti Tag CoIP
33961781
Intra
RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Validated Y2H
32296183
Intra
RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Y2H Array
32296183
Intra
RPP14 O95059 EXOSC8 Homo sapiens Q96B26
Y2H Prey Pooling
32296183
Intra
RPP14 O95059 ACTN2 Homo sapiens P35609
Validated Y2H
32296183
Intra
RPP14 O95059 ACTN2 Homo sapiens P35609
Y2H Prey Pooling
32296183
Intra
RPP14 O95059 ACTN2 Homo sapiens P35609
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Anauxetic Dysplasia 1

  • Anauxetic Dysplasia

  • Spondylometaepiphyseal Dysplasia, Menger Type

  • Spondylometaepiphyseal Dysplasia, Anauxetic Type

  • Spondyloepimetaphyseal Dysplasia, Anauxetic Type

  • ANXD1

  • Anxd

  • Spondylometaepiphyseal Dysplasia Anauxetic Type

  • Spondylometaepiphyseal Dysplasia Menger Type

  • Ad

  • Spondyloepimetaphyseal Dysplasia, Menger Type

  • Dysplasia, Anauxetic, Type 1
Chromosome 16p11.2 Deletion Syndrome

  • Distal 16p11.2 Microdeletion Syndrome

  • 16p11.2 Deletion Syndrome

  • Del(16)(P11.2)

  • Microdeletion 16p11.2

  • Monosomy 16p11.2

  • Autism, Susceptibility To, 14a

  • Auts14a

  • Distal Del(16)(P11.2)

  • Distal Monosomy 16p11.2
Cartilage-Hair Hypoplasia

  • Metaphyseal Chondrodysplasia, Mckusick Type

  • CHH

  • Mckusick Type Metaphyseal Chondrodysplasia

  • Metaphyseal Dysplasia Without Hypotrichosis

  • Cartilage Hair Hypoplasia Like Syndrome

  • Metaphyseal Chondrodysplasia Mckusick Type

  • Chhv

  • Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only

  • Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency

  • Cartilage-Hair Syndrome

  • Mckusick'S Metaphyseal Chondrodysplasia Syndrome

  • Metaphyseal Chondrodysplasia, Recessive Type

  • Autosomal Recessive Metaphyseal Chondrodysplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12212 RPP14 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RPP14 RGD RGD:1305436
Canis familiaris RPP14 VGNC VGNC:108255
Mus musculus RPP14 MGD MGI:1914303
Bos taurus RPP14 VGNC VGNC:109387
Others RPP14 NCBI