2. Metabolic Enzyme/Protease
  3. Aminopeptidase
  4. JNJ-26993135

JNJ-26993135 is a selective leukotriene A4 hydrolase (LTA4H) inhibitor with the IC50 value of 11 nM.

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JNJ-26993135

JNJ-26993135 Chemische Struktur

CAS. Nr. : 841202-16-2

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JNJ-26993135 Related Antibodies

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CD13 LTA4H

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Beschreibung

JNJ-26993135 is a selective leukotriene A4 hydrolase (LTA4H) inhibitor with the IC50 value of 11 nM[1].

Cellular Effect
Cell Line Type Value Description References
HEK293 IC50
> 30 μM
Compound: 33r
Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane
Displacement of [3H]astemizole from human ERG potassium channel expressed in HEK293 cell membrane
[PMID: 18588282]
Molekulargewicht

368.45

Formel

C20H20N2O3S
CAS. Nr.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1CCN(CC2=CC=C(OC3=NC4=CC=CC=C4S3)C=C2)CC1)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 12.5 mg/mL (33.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7141 mL 13.5704 mL 27.1407 mL
5 mM 0.5428 mL 2.7141 mL 5.4281 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation

Purity: 99.30%

SDS (251 KB)

COA (247 KB) HNMR (376 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7141 mL 13.5704 mL 27.1407 mL 67.8518 mL
5 mM 0.5428 mL 2.7141 mL 5.4281 mL 13.5704 mL
10 mM 0.2714 mL 1.3570 mL 2.7141 mL 6.7852 mL
15 mM 0.1809 mL 0.9047 mL 1.8094 mL 4.5235 mL
20 mM 0.1357 mL 0.6785 mL 1.3570 mL 3.3926 mL
25 mM 0.1086 mL 0.5428 mL 1.0856 mL 2.7141 mL
30 mM 0.0905 mL 0.4523 mL 0.9047 mL 2.2617 mL
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JNJ-26993135 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ-26993135841202-16-2JNJ26993135JNJ 26993135Aminopeptidaseasthmaallergic rhinitisInhibitorinhibitorinhibit

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