NELL2 - neural EGFL like 2 Gene

Also Known as NRP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4753

About NELL2

Cytogenetic location: 12q12 Genomic coordinates (GRCh38): 12:44,508,275-44,921,848 (from NCBI)

This gene has 20 transcripts (splice variants), 240 orthologues and 1 paralogue. Biased expression in brain (RPKM 55.4), duodenum (RPKM 9.0) and 5 other tissues.

Summary

The protein encoded by this gene is a glycoprotein containing several von Willebrand factor C domains and epidermal growth factor (EGF)-like domains. The encoded protein acts as a homotrimer and is found in the cytoplasm. Several variants encoding a few different isoforms exist, and at least one isoform appears to be a secreted protein. Studies in mouse suggest that this protein plays a role in neural cell growth and differentiation as well as in oncogenesis. [provided by RefSeq, Feb 2009]

NELL2 Products (5)

mRNA Protein Name
NM_001145107.2 NP_001138579.1 protein kinase C-binding protein NELL2 isoform a
NM_001145108.2 NP_001138580.1 protein kinase C-binding protein NELL2 isoform b precursor
NM_001145109.2 NP_001138581.1 protein kinase C-binding protein NELL2 isoform c precursor
NM_001145110.2 NP_001138582.1 protein kinase C-binding protein NELL2 isoform d
NM_006159.2 NP_006150.1 protein kinase C-binding protein NELL2 isoform b precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
32198364 GOA
enables identical protein binding IDA
IDA: Inferred from direct assay
32198364 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16713569 GOA
Biological Process GO Annotation Evidence References Source
involved in commissural neuron axon guidance IMP
IMP: Inferred from mutant phenotype
32198364 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NELL2 Protein Structure

Laminin_G_2

Laminin_G_2: Laminin G domain (96 - 210)

VWC

VWC: von Willebrand factor type C domain (274 - 330)

EGF_CA

EGF_CA: Calcium-binding EGF domain (440 - 473)

EGF_CA

EGF_CA: Calcium-binding EGF domain (484 - 521)

cEGF

cEGF: Complement Clr-like EGF-like (578 - 605)

VWC

VWC: von Willebrand factor type C domain (705 - 755)

  • 0
  • 200
  • 400
  • 600
  • 816 a.a.
Protein Preferred Names Protein Names

protein kinase C-binding protein NELL2

  • NEL-like protein 2

NELL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NELL2 Q99435 NUFIP2 Homo sapiens Q7Z417
Y2H Pooling
21653829
Intra
NELL2 Q99435 NUFIP2 Homo sapiens Q7Z417
Anti Tag CoIP
21653829
Intra
NELL2 Q99435 SHANK3 Homo sapiens Q9BYB0
Anti Tag CoIP
21653829
Intra
NELL2 Q99435 SHANK3 Homo sapiens Q9BYB0
Y2H Pooling
21653829
Intra
NELL2 Q99435 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Intra
NELL2 Q99435 HOXA1 Homo sapiens P49639
Anti Tag CoIP
21653829
Intra
NELL2 Q99435 MBD1 Homo sapiens Q9UIS9
Anti Tag CoIP
21653829
Intra
NELL2 Q99435 MBD1 Homo sapiens Q9UIS9
Y2H Pooling
21653829
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NELL2 Proteins

Cat. No. Product Name Accession Purity
HY-P75936 NELL2 Protein, Human (sf9, His) Q99435 (L22-L816) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Childhood Infratentorial Ependymoma

  • Pediatric Infratentorial Ependymoma
Childhood Ependymoma
Allergic Contact Dermatitis

  • Dermatitis, Allergic Contact

  • Contact Dermatitis, Allergic

  • Dermatitis Allergic Contact

  • Allergic Contact Eczema

  • Acd - [Allergic Contact Dermatitis]

  • Allergic Contact Dermatitis, Unspecified Cause

  • Allergic Dermatitis

  • Allergic Eczema

  • Allergy Dermatitis

  • Allergy Eczema

  • Allergic Contact Eczema Due To Clothing Or Footwear

  • Perfume Allergic Contact Dermatitis

  • Allergic Contact Dermatitis Due To Cosmetics

  • Allergic Contact Eczema Due To Cosmetics Or Fragrances

  • Allergic Contact Eczema Due To Dental Materials

  • Allergic Contact Eczema Due To Food Flavours Or Additives

  • Allergic Contact Eczema Due To Hairdressing Products

  • Allergic Contact Eczema Due To Metals Or Metal Salts

  • Allergic Contact Eczema Due To Proteins

  • Allergic Contact Eczema Due To Plastics Or Resin Systems

  • Allergic Contact Eczema Due To Preservatives Or Biocides

  • Allergic Contact Eczema Due To Rubber Chemicals

  • Rubber Dermatitis

  • Allergic Contact Eczema Due To Systemic Medicaments

  • Allergic Contact Eczema Due To Topical Medicaments

  • Allergic Contact Dermatitis Due To Drugs In Contact With Skin
Posterior Fossa Ependymoma
Spinal Cord Ependymoma

  • Ependymal Neoplasm Of The Spinal Cord

  • Spinal Ependymoma

  • Ependymoma Of Spinal Cord
Rela Fusion-Positive Ependymoma

  • Supratentorial C11orf95-Rela Fused Ependymoma

  • C11orf95 Fusion-Positive Supratentorial Ependymoma
High Grade Ependymoma

  • Ependymal Neoplasm

  • Ependymal Tumors

  • Malignant Ependymoma

  • Ependymal Tumor

  • Anaplastic Ependymoma

  • Experimental Organism Malignant Ependymoma

  • Ependymoma Of Brain
Cerebral Ventricle Cancer

  • Cerebral Ventricle Neoplasms

  • Cerebral Ventricle Neoplasm

  • Intraventricular Tumor Of Brain
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09205 NELL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19465 Nell2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25958 Nell2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus NELL2 MGD MGI:1858510
Rattus norvegicus NELL2 RGD RGD:620999
Macaca mulatta NELL2 VGNC VGNC:75313
Canis familiaris NELL2 VGNC VGNC:43740
Bos taurus NELL2 VGNC VGNC:32003
Felis catus NELL2 VGNC VGNC:68461
Others NELL2 NCBI