VDAC3 - voltage dependent anion channel 3 Gene
Also Known as VDAC-3; HD-VDAC3
Species: Homo sapiens
About VDAC3
This gene has 12 transcripts (splice variants), 304 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 97.4), testis (RPKM 53.6) and 25 other tissues.
Summary
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and Other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]
VDAC3 Products (12)
| mRNA | Protein | Name |
|---|---|---|
| NM_001135694.3 | NP_001129166.1 | voltage-dependent anion-selective channel protein 3 isoform 2 |
| NM_001413552.1 | NP_001400481.1 | voltage-dependent anion-selective channel protein 3 isoform 1 |
| NM_001413553.1 | NP_001400482.1 | voltage-dependent anion-selective channel protein 3 isoform 3 |
| NM_001413554.1 | NP_001400483.1 | voltage-dependent anion-selective channel protein 3 isoform 4 |
| NM_001413555.1 | NP_001400484.1 | voltage-dependent anion-selective channel protein 3 isoform 5 |
| NM_001413556.1 | NP_001400485.1 | voltage-dependent anion-selective channel protein 3 isoform 6 |
| NM_001413557.1 | NP_001400486.1 | voltage-dependent anion-selective channel protein 3 isoform 7 |
| NM_001413558.1 | NP_001400487.1 | voltage-dependent anion-selective channel protein 3 isoform 1 |
| NM_001413559.1 | NP_001400488.1 | voltage-dependent anion-selective channel protein 3 isoform 8 |
| NM_001413560.1 | NP_001400489.1 | voltage-dependent anion-selective channel protein 3 isoform 9 |
| NM_001413561.1 | NP_001400490.1 | voltage-dependent anion-selective channel protein 3 isoform 10 |
| NM_005662.7 | NP_005653.3 | voltage-dependent anion-selective channel protein 3 isoform 1 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
29128334 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in membrane |
IDA
IDA: Inferred from direct assay
|
27641616 | GOA |
VDAC3 Protein Structure
Porin_3: Eukaryotic porin (3 - 276)
- 0
- 100
- 200
- 283 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
voltage-dependent anion-selective channel protein 3 |
|
VDAC3 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
VDAC3 | Q9Y277 | VDAC2 | Homo sapiens | P45880 | 35271311 | |
|
Intra
|
VDAC3 | Q9Y277 | VDAC1 | Homo sapiens | P21796 | 35271311 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| 3-Methylglutaconic Aciduria, Type Iii |
|
|
| Parkinson Disease, Late-Onset |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | VDAC3 | VGNC | VGNC:82523 |
| Mus musculus | VDAC3 | MGD | MGI:106922 |
| Macaca mulatta | VDAC3 | VGNC | VGNC:84135 |
| Rattus norvegicus | VDAC3 | RGD | RGD:621577 |
| Canis familiaris | VDAC3 | VGNC | VGNC:48248 |
| Others | VDAC3 | NCBI |