TC-1698
TC-1698 is a selective α7 nicotinic acetylcholine receptors agonist with EC50 value of 0.16 μM and 0.46 μM for monkey α7 nicotinic receptor and human α7 nicotinic receptor, respectively. TC-1698 improves memory and has neuroprotective effects. TC-1698 can be used for Alzheimer's disease research.
For research use only. We do not sell to patients.
- CAS No.: 700834-58-8
- Formula: C13H18N2
- Molecular Weight:202.30
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
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Biological Activity
Description
Chemical Information
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CAS No. 700834-58-8
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Molecular Weight 202.30
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Formula C13H18N2
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SMILES
N1(CC2)C(C3=CC=CN=C3)CCC2CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.
Purity & Documentation
References
[1]. Mazurov AA, et al. Discovery and development of α7 nicotinic acetylcholine receptor modulators. J Med Chem. 2011 Dec 8;54(23):7943-61. [Content Brief]
[2]. Marrero MB, et al. The neuroprotective effect of 2-(3-pyridyl)-1-azabicyclo[3.2.2]nonane (TC-1698), a novel alpha7 ligand, is prevented through angiotensin II activation of a tyrosine phosphatase. J Pharmacol Exp Ther. 2004 Apr;309(1):16-27. [Content Brief]
[3]. Papke RL, et al. Rhesus monkey alpha7 nicotinic acetylcholine receptors: comparisons to human alpha7 receptors expressed in Xenopus oocytes. Eur J Pharmacol. 2005 Nov 7;524(1-3):11-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
TC-1698 Related Classifications
HY-107668A Related Classifications
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