6-Hydroxybenzbromarone
Based on 1 Customer Validation
6-Hydroxybenzbromarone is the major metabolite of Benzbromarone with a longer half-life and greater pharmacological potency than the parent compound. 6-Hydroxybenzbromarone is a protein Eyes Absent 3 (EYA3) inhibitor with an IC50 value of 21.5 μM. 6-Hydroxybenzbromarone is an anti-angiogenic agent, has strong inhibitory effects on cell migration, tubulogenesis, and angiogenic sprouting.
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- 純度: 99.21%
- CAS 番号: 152831-00-0
- 分子式: C17H12Br2O4
- 分子量:440.08
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
IC50: 21.5 μM (EYA3); metabolite[1]
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Cell Line
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Type | Value | Description | References |
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| MDCK | IC50 |
200 nM
Compound: 8, 6-hydroxybenzbromarone
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Inhibition of human URAT1 expressed in human MDCK cells
Inhibition of human URAT1 expressed in human MDCK cells
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[PMID: 21449597] |
6-Hydroxybenzbromarone (7.5 μM; 72 hours) shows over 50% reduction in cell proliferation. Meanwhile, treatment with BBR and BZ also reduces cell viability, but none of the other compounds tested has a negative impact on cell viability or proliferation[1]. 6-Hydroxybenzbromarone (7.5 μM; 1-20 hours) has inhibitory affects EC migration tubulogenesis of HUVECs. However, the effect of 6OH-BBR on tube formation is attenuated in the presence of high concentrations of fetal bovine serum (FBS), likely reflecting non-specific protein binding[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVEC cells
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Concentration:7.5 μM
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Incubation Time:72 hours
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Result:Inhibited HUVEC cells proliferation.
化学情報
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CAS 番号 152831-00-0
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性状 Solid
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分子量 440.08
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分子式 C17H12Br2O4
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Color Off-white to light yellow
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SMILES
O=C(C1=CC(Br)=C(O)C(Br)=C1)C2=C(CC)OC3=CC(O)=CC=C23
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 100 mg/mL (227.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2723 mL | 11.3616 mL | 22.7231 mL | 56.8079 mL |
| 5 mM | 0.4545 mL | 2.2723 mL | 4.5446 mL | 11.3616 mL | |
| 10 mM | 0.2272 mL | 1.1362 mL | 2.2723 mL | 5.6808 mL | |
| 15 mM | 0.1515 mL | 0.7574 mL | 1.5149 mL | 3.7872 mL | |
| 20 mM | 0.1136 mL | 0.5681 mL | 1.1362 mL | 2.8404 mL | |
| 25 mM | 0.0909 mL | 0.4545 mL | 0.9089 mL | 2.2723 mL | |
| 30 mM | 0.0757 mL | 0.3787 mL | 0.7574 mL | 1.8936 mL | |
| 40 mM | 0.0568 mL | 0.2840 mL | 0.5681 mL | 1.4202 mL | |
| 50 mM | 0.0454 mL | 0.2272 mL | 0.4545 mL | 1.1362 mL | |
| 60 mM | 0.0379 mL | 0.1894 mL | 0.3787 mL | 0.9468 mL | |
| 80 mM | 0.0284 mL | 0.1420 mL | 0.2840 mL | 0.7101 mL | |
| 100 mM | 0.0227 mL | 0.1136 mL | 0.2272 mL | 0.5681 mL |
6-Hydroxybenzbromarone 関連分類
HY-135774 関連分類
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