8-Hydroxyefavirenz
Based on 1 Customer Validation
8-Hydroxyefavirenz (8-OH-EFV) is a primary metabolite of (HY-10572). 8-Hydroxyefavirenz induces apoptosis via a JNK- and BimEL-dependent mechanism in primary human hepatocytes. 8-Hydroxyefavirenz can be used in research of cancer. 8-Hydroxyefavirenz is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 97.01%
- CAS 番号: 205754-33-2
- 分子式: C14H9ClF3NO3
- 分子量:331.67
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保管条件:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
体外実験
8-Hydroxyefavirenz (8-OH-EFV; 1-10 μM; 3-24 h; primary human hepatocytes) increases cell death in a time- and concentration-dependent manner and induces caspase-3 activity beginning at 6 h[1].
8-Hydroxyefavirenz (1-10 μM; 6-24 h) stimulates mitochondria ROS production in primary human hepatocytes[1].
8-Hydroxyefavirenz (10 μM; 3-24 h) activates JNK and increases the ratio of phosphorylated JNK to total JNK by 4.2-fold. 8-Hydroxyefavirenz increases the mRNA and protein expression of BimEL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased cell death in a time- and concentration-dependent manner and increased cell death by 3.4-fold at 6 h.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased the expression of cleaved caspase-3 in a time- and concentration-dependent manner.
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Cell Line:Primary human hepatocytes
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Concentration:1 and 10 μM
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Incubation Time:3, 6, 12 and 24 hours
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Result:Increased the phosphorylation of JNK and increased the mRNA and protein expression of BimEL.
化学情報
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CAS 番号 205754-33-2
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性状 Solid
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分子量 331.67
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分子式 C14H9ClF3NO3
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Color White to off-white
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SMILES
O=C1NC2=C(O)C=C(Cl)C=C2[C@](C(F)(F)F)(C#CC3CC3)O1
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別名
8-OH-EFV
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
体外:
DMSO : 250 mg/mL (753.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (279 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0150 mL | 15.0752 mL | 30.1504 mL | 75.3761 mL |
| 5 mM | 0.6030 mL | 3.0150 mL | 6.0301 mL | 15.0752 mL | |
| 10 mM | 0.3015 mL | 1.5075 mL | 3.0150 mL | 7.5376 mL | |
| 15 mM | 0.2010 mL | 1.0050 mL | 2.0100 mL | 5.0251 mL | |
| 20 mM | 0.1508 mL | 0.7538 mL | 1.5075 mL | 3.7688 mL | |
| 25 mM | 0.1206 mL | 0.6030 mL | 1.2060 mL | 3.0150 mL | |
| 30 mM | 0.1005 mL | 0.5025 mL | 1.0050 mL | 2.5125 mL | |
| 40 mM | 0.0754 mL | 0.3769 mL | 0.7538 mL | 1.8844 mL | |
| 50 mM | 0.0603 mL | 0.3015 mL | 0.6030 mL | 1.5075 mL | |
| 60 mM | 0.0503 mL | 0.2513 mL | 0.5025 mL | 1.2563 mL | |
| 80 mM | 0.0377 mL | 0.1884 mL | 0.3769 mL | 0.9422 mL | |
| 100 mM | 0.0302 mL | 0.1508 mL | 0.3015 mL | 0.7538 mL |
8-Hydroxyefavirenz 関連分類
HY-137397 関連分類
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