Fosmidomycin sodium salt
Based on 2 publication(s) in Google Scholar
Fosmidomycin sodium salt is a phosphonic acid antibiotic and a antimalarial agent, which is active against both Gram-negative and Gram-positive bacteria.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.72%
- CAS 番号: 66508-37-0
- 分子式: C4H9NNaO5P
- 分子量:205.08
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保管条件:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Fosmidomycin sodium salt
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MRC5 | CC50 |
>64 μM
Compound: 1
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Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
Cytotoxicity in human MRC5 cells assessed as reduction in cell viability incubated for 24 hrs by resazurin-based cytotoxicity assay
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[PMID: 30879839] |
| MRC5 | CC50 |
>64 μM
Compound: 1
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability
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[PMID: 36399924] |
| MRC5 | IC50 |
>64 μM
Compound: 1
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Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
Cytotoxicity against human MRC5 cells after 24 hrs by resazurin assay
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[PMID: 30344904] |
Fosmidomycin sodium salt is a phosphonic acid antibiotic[1][2], which is active against both Gram-negative and Gram-positive bacteria[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 66508-37-0
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性状 Solid
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分子量 205.08
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分子式 C4H9NNaO5P
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Color White to light brown
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SMILES
OP(CCCN(C=O)O)(O[Na])=O
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別名
FR-31564
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Plant Sci
Adjusting function of camphor on primary metabolism in Cinnamomum camphora stressed by high temperature. [Abstract]2024 Feb:339:111956. PMID: 38101618 -
ACS Infect Dis
Integral Solvent-Induced Protein Precipitation for Target-Engagement Studies in Plasmodium falciparum. [Abstract]2024 Dec 13;10(12):4073-4086. PMID: 39631773
溶剤 & 溶解度
H2O : 25 mg/mL (121.90 mM; ultrasonic and warming and heat to 60°C)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 100 mg/mL (487.61 mM); Clear solution; Need ultrasonic
純度とドキュメンテーション
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データシート (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kojo H, et al. FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability. J Antibiot (Tokyo). 1980 Jan;33(1):44-8. [Content Brief]
[2]. Fernandes JF, et al. Fosmidomycin as an antimalarial drug: a meta-analysis of clinical trials. Future Microbiol. 2015;10(8):1375-90. [Content Brief]
[3]. Jomaa H, et al. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science. 1999 Sep 3;285(5433):1573-6. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 4.8761 mL | 24.3807 mL | 48.7615 mL | 121.9036 mL |
| 5 mM | 0.9752 mL | 4.8761 mL | 9.7523 mL | 24.3807 mL | |
| 10 mM | 0.4876 mL | 2.4381 mL | 4.8761 mL | 12.1904 mL | |
| 15 mM | 0.3251 mL | 1.6254 mL | 3.2508 mL | 8.1269 mL | |
| 20 mM | 0.2438 mL | 1.2190 mL | 2.4381 mL | 6.0952 mL | |
| 25 mM | 0.1950 mL | 0.9752 mL | 1.9505 mL | 4.8761 mL | |
| 30 mM | 0.1625 mL | 0.8127 mL | 1.6254 mL | 4.0635 mL | |
| 40 mM | 0.1219 mL | 0.6095 mL | 1.2190 mL | 3.0476 mL | |
| 50 mM | 0.0975 mL | 0.4876 mL | 0.9752 mL | 2.4381 mL | |
| 60 mM | 0.0813 mL | 0.4063 mL | 0.8127 mL | 2.0317 mL | |
| 80 mM | 0.0610 mL | 0.3048 mL | 0.6095 mL | 1.5238 mL | |
| 100 mM | 0.0488 mL | 0.2438 mL | 0.4876 mL | 1.2190 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Fosmidomycin sodium salt 関連分類
HY-112853 関連分類
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