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United States

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製品番号: HY-182280

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BDM71230

BDM71230 is an orally active inducer of insulin-degrading enzyme (IDE), with an EC₅₀ of 1.9 μM against human IDE. BDM71230 binds to the interface of IDE dimers and enhances the catalytic activity of IDE via steric effects. BDM71230 can potentiate the hydrolytic effect of IDE on insulin and slightly attenuate the hypoglycemic effect of insulin. BDM71230 serves as a pharmacological tool for investigating IDE function and is applicable to studies related to glucose intolerance.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₅H₂₆FN₅O
分子量:431.51

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

BDM71230 構造式

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- 体外実験
- Parmacokinetics
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

体外実験

BDM71230 (1.9-100 μM) potently activates recombinant human IDE catalytic activity with an EC₅₀ of 1.9 μM and a 4.1-fold maximum activation at 100 μM^[1].
BDM71230 (10 μM; overnight pre-treatment, 1 h glucose stimulation) significantly reduces glucose-stimulated insulin secretion in Min6 murine pancreatic β-cells across low, medium, and high glucose concentrations^[1].
BDM71230 (10 μM; up to 24 h) is highly stable in mouse plasma with a half-life exceeding 24 h^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

Murine Min6 pancreatic β-cells
Concentration:

10 μM
Incubation Time:

overnight (pre-treatment); 1 h (glucose stimulation)
Result:

Significantly decreased secreted insulin levels in Min6 cells stimulated with 2.8 mM, 11 mM, or 20 mM glucose.

Parmacokinetics

Species	Dose	Route	C_max	T_1/2
Mice^[1]	30 mg/kg	i.p.	5.3 μg/mL	81 min

体内実験

BDM71230 (50 mg/kg; i.p.; single dose) significantly increases glucose intolerance in mice during an oral glucose tolerance test and slightly blunts insulin's glucose-lowering effect during an insulin tolerance test^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6J (male, 14 weeks old for OGTT; male, 5-hour fasted for ITT)^[1]
Dosage:

50 mg/kg
Administration:

i.p.; single dose
Result:

Significantly increased blood glucose levels at 45, 75, and 105 minutes post-glucose challenge during OGTT compared to vehicle.
Slightly decreased the glucose-lowering effect of insulin at 30 minutes post-insulin injection during ITT.

化学情報

分子量 431.51
分子式 C₂₅H₂₆FN₅O
SMILES

O=C(N1CCC2=C(C=CC=C2)C1)C3CCN(C4=NC=CC(NC5=CC=C(C=C5)F)=N4)CC3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. El Bakali J, et al. Discovery of pyrimidine-based small activators of insulin degrading enzyme. Eur J Med Chem. 2026;309:118740. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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