BLK-IN-1
BLK-IN-1 (compound 1) is a selective and covalent inhibitor of B-Lymphoid tyrosine kinase (BLK) and BTK, with IC50s of 18.8 nM and 20.5 nM, respectively. BLK-IN-1 can be used for the research of cancer.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1431727-00-2
- 分子式: C29H23F3N6O3
- 分子量:560.53
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 18.8 nM (BLK), 20.5 nM (BTK)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DOHH-2 | GI50 |
0.073 μM
Compound: 31
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Cytotoxicity against human DOHH2 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human DOHH2 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 24915291] |
| Pfeiffer | GI50 |
0.008 μM
Compound: 31
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Cytotoxicity against human Pfeiffer cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human Pfeiffer cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 24915291] |
| Ramos | IC50 |
14 nM
Compound: 31
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Inhibition of Btk phosphorylation at Tyr551 in human Ramos cells after 1 hr by Western blot analysis
Inhibition of Btk phosphorylation at Tyr551 in human Ramos cells after 1 hr by Western blot analysis
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[PMID: 24915291] |
| Ramos | IC50 |
8.5 nM
Compound: 31
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Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysis
Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysis
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[PMID: 24915291] |
| SU-DHL-6 | GI50 |
0.038 μM
Compound: 31
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Cytotoxicity against human SU-DHL6 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human SU-DHL6 cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 24915291] |
| WSU-NHL | GI50 |
0.031 μM
Compound: 31
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Cytotoxicity against human WSU-NHL cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
Cytotoxicity against human WSU-NHL cells assessed as growth inhibition after 72 hrs by CellTiter-Glo luminescent cell viability assay
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[PMID: 24915291] |
化学情報
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CAS 番号 1431727-00-2
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分子量 560.53
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分子式 C29H23F3N6O3
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SMILES
O=C(NC1=CN=C(NC2=CC=CC(NC(C=C)=O)=C2)N=C1)C3=CC(NC(C4=CC=CC(C(F)(F)F)=C4)=O)=CC=C3C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BLK-IN-1 関連分類
HY-144283 関連分類
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