Cotadutide
Based on 1 publication(s) in Google Scholar
Cotadutide (MEDI0382) is a potent dual agonist of glucagon-like peptide-1 (GLP-1) and GCGR with EC50 values of 6.9 pM and 10.2 pM, respectively. Cotadutide exhibits ability to facilitate both weight loss and glycaemic control, and alleviate fibrosis. Cotadutide can be used in the research of obesity and type 2 diabetes (T2D).
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.80%
- CAS 番号: 1686108-82-6
- 分子式: C167H252N42O55
- 分子量:3728.09
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Cotadutide
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生物活性
EC50: 6.9 pM (GLP-1); 10.2 pM (GCGR)[1]
Cotadutide stimulates a concentration-dependent increase in cAMP accumulation in rat (INS-1 832/3) and human (EndoC-βH1) β-cell lines (EC50: 226 pM and 1051 pM, respectively), as well as rat, mouse and human hepatocytes (EC50: 462 pM, 840 pM, 1447 pM, respectively)[1]. Cotadutide (100 pM-1 μM) potentiates glucose-stimulated insulin secretion in the rat (INS-1 832/3) pancreatic β-cell line and increases glucose output in rat hepatocytes[1]. Cotadutide (100 nM, 2 h) induces mitochondrial turnover and enhances mitochondrial function in mouse primary hepatocytes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:10 nmol/kg
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Administration:Subcutaneousinjection (s.c.)
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Result:Showed a redction of food intake in mice after an acute administration.
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Animal Model:Diet-induced obesity (DIO) mice[1]
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Dosage:10 or 30 nmol/kg
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Administration:Subcutaneousinjection (s.c.)
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Result:Reduced body weight and food intake, and improved glucose tolerance in DIO mice.
化学情報
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CAS 番号 1686108-82-6
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性状 Solid
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分子量 3728.09
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分子式 C167H252N42O55
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Color White to off-white
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別名
MEDI0382
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配列
His-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-{Lys(γGlu-C16 acid)}-Ser-Glu-Tyr-Leu-Asp-Ser-Glu-Arg-Ala-Arg-Asp-Phe-Val-Ala-Trp-Leu-Glu-Ala-Gly-Gly
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シーケンスの短縮
HSQGTFTSD-{Lys(γGlu-C16 acid)}-SEYLDSERARDFVAWLEAGG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (1)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
2024 Aug;11(29):e2400819. PMID: 38837628
溶剤 & 溶解度
DMSO : 100 mg/mL (26.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (287 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Henderson SJ,et al. Robust anti-obesity and metabolic effects of a dual GLP-1/glucagon receptor peptide agonist in rodents and non-human primates.Diabetes Obes Metab. 2016 Dec;18(12):1176-1190. [Content Brief]
[2]. Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis. Nat Metab. 2020 May;2(5):413-431. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 0.2682 mL | 1.3412 mL | 2.6823 mL | 6.7058 mL |
| 5 mM | 0.0536 mL | 0.2682 mL | 0.5365 mL | 1.3412 mL | |
| 10 mM | 0.0268 mL | 0.1341 mL | 0.2682 mL | 0.6706 mL | |
| 15 mM | 0.0179 mL | 0.0894 mL | 0.1788 mL | 0.4471 mL | |
| 20 mM | 0.0134 mL | 0.0671 mL | 0.1341 mL | 0.3353 mL | |
| 25 mM | 0.0107 mL | 0.0536 mL | 0.1073 mL | 0.2682 mL |
Cotadutide 関連分類
HY-P2231 関連分類
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