eIF4A3-IN-9
Based on 1 Customer Validation
eIF4A3-IN-9 is a Rocaglate analog. eIF4A3-IN-9 interferes with the assembly of the eIF4F translation complex, with EC50 values of 29 and 450 nM against myc-LUC and tub-LUC, respectively. eIF4A3-IN-9 can be used for the research of tumor pathogenesis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.71%
- CAS 番号: 1402931-71-8
- 分子式: C28H27NO8
- 分子量:505.52
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保管条件:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
製品説明
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| MDA-MB-231 | EC50 |
29 nM
Compound: 57
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Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
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[PMID: 23025805] |
| MDA-MB-231 | EC50 |
450 nM
Compound: 57
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Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
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[PMID: 23025805] |
| MDA-MB-231 | EC50 |
80 nM
Compound: 57
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Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
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[PMID: 23025805] |
体外実験
eIF4A3-IN-9 (Compound 57) (24-72 h) selectively inhibits the translation of mRNAs with highly structured 5′UTRs (such as c-myc) in MDA-MB-231 cells, while exerts weak inhibitory effects on the translation of mRNAs with simple 5′UTRs (such as tubulin); its EC50 values against myc-LUC and tub-LUC are 29 nM and 450 nM, respectively, and the EC50 for inhibiting the proliferation of MDA-MB-231 cells is 80 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1402931-71-8
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性状 Solid
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分子量 505.52
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分子式 C28H27NO8
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Color White to off-white
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SMILES
O[C@]12[C@](OC3=CC(C(N)=O)=CC(OC)=C32)(C4=CC=C(C=C4)OC)[C@H](C5=CC=CC=C5)[C@H]([C@H]1O)C(OC)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
純度とドキュメンテーション
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データシート (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
eIF4A3-IN-9 関連分類
HY-148443 関連分類
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