FR-146687
FR-146687 (FK 687) is a selective and orally active 5α-reductase inhibitor with IC50s of 1.7 nM and 4.6 nM for rat and human 5α-reductases, respectively. FR-146687 shows no inhibitory effects on other steroid oxidoreductases.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 146939-64-2
- 分子式: C33H37NO4
- 分子量:511.65
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 1.7 nM (Rat 5α-reductase) and 4.6 nM (Human 5α-reductase)[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4-week-old immature castrated male rats injected with Testosterone propionate (TP)[1]
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Dosage:0.032 mg/kg, 0.32 mg/kg, 3.2 mg/kg
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Administration:po; 2, 7, 14, or 21 days
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Result:Dose-dependently reduced ventral prostate and seminal vesicle weight at doses above 0.1 mg/kg.
化学情報
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CAS 番号 146939-64-2
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分子量 511.65
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分子式 C33H37NO4
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SMILES
O=C(O)CCCC1=CC(C(C2=CC=C(O[C@H](C3=CC=C(CC(C)C)C=C3)CCC)C=C2)=O)=C4C=CC=CN14
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別名
FK 687; TF 505
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
FR-146687 関連分類
HY-19284 関連分類
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