POP4 - POP4 homolog, ribonuclease P/MRP subunit Gene

Also Known as RPP29

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 10775

About POP4

Cytogenetic location: 19q12 Genomic coordinates (GRCh38): 19:29,606,283-29,617,237 (from NCBI)

This gene has 13 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in testis (RPKM 7.0), lymph node (RPKM 6.7) and 25 other tissues.

Summary

This gene encodes one of the protein subunits of the small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is localized to the nucleus and associates directly with the RNA component of these complexes. This protein is involved in processing of precursor RNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

POP4 Products (1)

mRNA	Protein	Name
NM_006627.3	NP_006618.1	ribonuclease P protein subunit p29

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	15096576	GOA
enables ribonuclease P RNA binding	IDA IDA: Inferred from direct assay	16723659	GOA
contributes to ribonuclease P activity	IDA IDA: Inferred from direct assay	30454648	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in tRNA 5'-leader removal	IDA IDA: Inferred from direct assay	16723659	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of multimeric ribonuclease P complex	IDA IDA: Inferred from direct assay	16723659	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	10444065	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POP4 Protein Structure

UPF0086

0
100
200
220 a.a.

Protein Preferred Names	Protein Names
ribonuclease P protein subunit p29	hPOP4

POP4 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	POP4	O95707	RPP38	Homo sapiens	P78345	Anti Tag CoIP	33961781
Intra	POP4	O95707	RPP38	Homo sapiens	P78345	Anti Tag CoIP	28514442
Intra	POP4	O95707	RPP38	Homo sapiens	P78345	Pull Down	15096576
Intra	POP4	O95707	POP5	Homo sapiens	Q969H6	Anti Tag CoIP	33961781
Intra	POP4	O95707	POP5	Homo sapiens	Q969H6	Anti Tag CoIP	28514442
Intra	POP4	O95707	POP5	Homo sapiens	Q969H6	Pull Down	15096576
Intra	POP4	O95707	RPP14	Homo sapiens	O95059	Anti Tag CoIP	28514442
Intra	POP4	O95707	RPP14	Homo sapiens	O95059	Anti Tag CoIP	33961781
Intra	POP4	O95707	RPP25	Homo sapiens	Q9BUL9	Anti Tag CoIP	33961781
Intra	POP4	O95707	RPP25	Homo sapiens	Q9BUL9	Anti Tag CoIP	28514442
Intra	POP4	O95707	RPP25	Homo sapiens	Q9BUL9	Pull Down	15096576
Intra	POP4	O95707	POP1	Homo sapiens	Q99575	Anti Tag CoIP	28514442
Intra	POP4	O95707	POP1	Homo sapiens	Q99575	Pull Down	15096576
Intra	POP4	O95707	POP1	Homo sapiens	Q99575	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Diamond-Blackfan Anemia 2	DBA2 Anemia, Diamond-Blackfan, 2 Anemia Diamond-Blackfan 2
Intracystic Papillary Adenoma	Intracystic Papilloma
Anauxetic Dysplasia 2	ANXD2
Anauxetic Dysplasia 1	Anauxetic Dysplasia Spondylometaepiphyseal Dysplasia, Menger Type Spondylometaepiphyseal Dysplasia, Anauxetic Type Spondyloepimetaphyseal Dysplasia, Anauxetic Type ANXD1 Anxd Spondylometaepiphyseal Dysplasia Anauxetic Type Spondylometaepiphyseal Dysplasia Menger Type Ad Spondyloepimetaphyseal Dysplasia, Menger Type Dysplasia, Anauxetic, Type 1
Periampullary Adenocarcinoma
Dihydropyrimidine Dehydrogenase Deficiency	Dpd Deficiency Familial Pyrimidinemia Hereditary Thymine-Uraciluria Dihydropyrimidinuria Dpyd Deficiency Thymine-Uraciluria, Hereditary Pyrimidinemia, Familial 5-Fluorouracil Toxicity Dihydrouracil Dehydrogenase Deficiency Familial Pyrimidinaemia Thymine-Uracilurea Familial Pyrimidemia Pyrimidinemia Familial DPYDD
Cartilage-Hair Hypoplasia	Metaphyseal Chondrodysplasia, Mckusick Type CHH Mckusick Type Metaphyseal Chondrodysplasia Metaphyseal Dysplasia Without Hypotrichosis Cartilage Hair Hypoplasia Like Syndrome Metaphyseal Chondrodysplasia Mckusick Type Chhv Cartilage-Hair Hypoplasia Variant, Skeletal Manifestations Only Cartilage-Hair Hypoplasia-Like Skeletal Dysplasia Without Hypotrichosis Or Immunodeficiency Cartilage-Hair Syndrome Mckusick'S Metaphyseal Chondrodysplasia Syndrome Metaphyseal Chondrodysplasia, Recessive Type Autosomal Recessive Metaphyseal Chondrodysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS10876	POP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Felis catus	POP4	VGNC	VGNC:64298
Rattus norvegicus	POP4	RGD	RGD:1305955
Mus musculus	POP4	MGD	MGI:1913411
Bos taurus	POP4	VGNC	VGNC:33164
Canis familiaris	POP4	VGNC	VGNC:44816
Macaca mulatta	POP4	VGNC	VGNC:76140
Others	POP4	NCBI