CLUAP1 - clusterin associated protein 1 Gene

Also Known as FAP22; IFT38; CFAP22

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 23059

About CLUAP1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,495,427-3,539,048 (from NCBI)

This gene has 12 transcripts (splice variants), 211 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 8.8), endometrium (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene contains a single coiled-coil region. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Jul 2012]

CLUAP1 Products (3)

mRNA	Protein	Name
NM_001330454.2	NP_001317383.1	clusterin-associated protein 1 isoform 3
NM_015041.3	NP_055856.1	clusterin-associated protein 1 isoform 1
NM_024793.3	NP_079069.1	clusterin-associated protein 1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
part of intraciliary transport particle B	IPI IPI: Inferred from physical interaction	26980730	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLUAP1 Protein Structure

Cluap1

0
100
200
300
413 a.a.

Protein Preferred Names	Protein Names
clusterin-associated protein 1	cilia and flagella associated protein 22

CLUAP1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	CLUAP1	Q96AJ1	MAGEA11	Homo sapiens	P43364-2	Y2H Array	25416956
Intra	CLUAP1	Q96AJ1	MYOG	Homo sapiens	P15173	Y2H Array	31515488
Intra	CLUAP1	Q96AJ1	MYOG	Homo sapiens	P15173	Y2H Array	25416956
Intra	CLUAP1	Q96AJ1	MYOG	Homo sapiens	P15173	Y2H Array	32296183
Intra	CLUAP1	Q96AJ1	MYOG	Homo sapiens	P15173	Y2H Prey Pooling	32296183
Intra	CLUAP1	Q96AJ1	MAGEA11	Homo sapiens	P43364	Y2H Prey Pooling	32296183
Intra	CLUAP1	Q96AJ1	MAGEA11	Homo sapiens	P43364	Pull Down	16189514
Intra	CLUAP1	Q96AJ1	MAGEA11	Homo sapiens	P43364	Y2H Array	32296183
Intra	CLUAP1	Q96AJ1	CRACR2A	Homo sapiens	Q9BSW2	Anti Tag CoIP	33961781
Intra	CLUAP1	Q96AJ1	CRACR2A	Homo sapiens	Q9BSW2	Anti Tag CoIP	28514442
Intra	CLUAP1	Q96AJ1	CINP	Homo sapiens	Q9BW66	Y2H Pooling	16189514
Intra	CLUAP1	Q96AJ1	CINP	Homo sapiens	Q9BW66	Y2H Array	31515488
Intra	CLUAP1	Q96AJ1	CINP	Homo sapiens	Q9BW66	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Leber Plus Disease	Leber Congenital Amaurosis Lca Leber'S Amaurosis Leber'S Disease Amaurosis Congenita Of Leber Amaurosis Congenita Of Leber, Type 1 Lhon Plus Disease Congenital Absence Of The Rods And Cones Congenital Retinal Blindness Crb Congenital Amaurosis Of Retinal Origin Leber'S Congenital Amaurosis Leber Congenital Amaurosis 1 Leber'S Congenital Tapetoretinal Degeneration Leber'S Congenital Tapetoretinal Dysplasia Lca1 Leber Congenital Amaurosis Type 1 Retinal Blindness, Congenital Amaurosis, Leber Congenital Dysgenesis Neuroepithelialis Retinae Hereditary Epithelial Dysplasia Of Retina Hereditary Retinal Aplasia Heredoretinopathia Congenitalis Leber Abiotrophy Leber Congenital Tapetoretinal Degeneration Lebers Congenital Amaurosis Optic Atrophy, Hereditary, Leber
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Leber Congenital Amaurosis 15	LCA15 Leber Congenital Amaurosis, Type 15
Cone-Rod Dystrophy 18	CORD18 Dystrophy, Cone-Rod, Type 18
Short-Rib Thoracic Dysplasia 7 With Or Without Polydactyly	SRTD7 Srps5 Short Rib-Polydactyly Syndrome Type V Short-Rib Thoracic Dysplasia 7/20 With Polydactyly, Digenic Short Rib-Polydactyly Syndrome, Type V Short Rib-Polydactyly Syndrome Type 5 Srps Type V SRTD7/20 Short-Rib Thoracic Dysplasia 7 Without Polydactyly
Bardet-Biedl Syndrome	Bbs Biedl-Bardet Syndrome
Short-Rib Thoracic Dysplasia 3 With Or Without Polydactyly	Asphyxiating Thoracic Dystrophy 3 Saldino-Noonan Syndrome SRTD3 Atd3 Srps1 Srps3 Verma-Naumoff Syndrome Srps2b Short Rib-Polydactyly Syndrome, Verma-Naumoff Type Short Rib-Polydactyly Syndrome, Type I Polydactyly With Neonatal Chondrodystrophy, Type I Polydactyly With Neonatal Chondrodystrophy, Type Iii Short Rib-Polydactyly Syndrome, Type Iib Short Rib-Polydactyly Syndrome Type 3 Polydactyly With Neonatal Chondrodystrophy Type Iii Short Rib-Polydactyly Syndrome Type Iii Short Rib-Polydactyly Syndrome Type 1 Short Rib-Polydactyly Syndrome, Saldino-Noonan Type Majewski Syndrome Short Rib-Polydactyly Syndrome, Type Iii Type I Short Rib Polydactyly Syndrome Srps Type 3 Short Rib Polydactyly Syndrome Verma Naumoff Type Verma Naumoff Syndrome Polydactyly With Neonatal Chondrodystrophy Type 1 Srps Type 1 Short Rib-Polydactyly Syndrome Saldino-Noonan Type Jatd Jeune Asphyxiating Thoracic Dystrophy Jeune Syndrome 3 Polydactyly With Neonatal Chondrodystrophy Type I Short Rib-Polydactyly Syndrome Type I Short Rib-Polydactyly Syndrome Type Iib Srps Type Iib Srps Type Iii
Short-Rib Thoracic Dysplasia 9 With Or Without Polydactyly	Conorenal Syndrome Saldino-Mainzer Syndrome SRTD9 Mainzer-Saldino Syndrome Mzsds Mainzer-Saldino Disease Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia, And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dysplasia Renal Dysplasia, Retinal Pigmentary Dystrophy, Cerebellar Ataxia And Skeletal Dy Mainzer Saldino Syndrome Conorenal Dysplasia Mainzer-Saldino Chondrodysplasia Saldino-Mainzer Dysplasia Short-Rib Thoracic Dysplasia 9 Renal Dysplasia-Retinal Pigmentary Dystrophy-Cerebellar Ataxia-Skeletal Dysplasia Syndrome Mss Renal Dysplasia Retinal Pigmentary Dystrophy Cerebellar Ataxia And Skeletal Dysplasia
Senior-Loken Syndrome 1	Senior-Loken Syndrome Renal Dysplasia And Retinal Aplasia Renal-Retinal Syndrome Loken-Senior Syndrome Juvenile Nephronophthisis With Leber Amaurosis SLSN1 Senior-Loken Syndrome-1 Loken Senior Syndrome Senior Loken Syndrome Renal Dysplasia Retinal Aplasia Nephronophthisis With Retinal Dystrophy Renal Dysplasia-Retinal Aplasia Syndrome Slsn
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Fundus Dystrophy	Retinal Dystrophy Retinal Dystrophies Dystrophy, Retinal
Cone-Rod Dystrophy 2	Cone-Rod Dystrophy CORD2 Cone-Rod Retinal Dystrophy Rcrd2 Cone-Rod Retinal Dystrophy 2 Crd2 Cord Crd Retinal Cone-Rod Dystrophy Cone-Rod Retinal Dystrophy-2 Retinal Cone-Rod Dystrophy 2 Tapetoretinal Degeneration Cone-Rod Degeneration Cone Rod Dystrophy Dystrophy, Cone-Rod Dystrophy, Cone-Rod, Type 2 Retinitis Pigmentosa Retinitis Pigmentosa 2 Progressive Cone-Rod Dystrophy
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS02849	CLUAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Macaca mulatta	CLUAP1	VGNC	VGNC:71211
Canis familiaris	CLUAP1	VGNC	VGNC:39370
Rattus norvegicus	CLUAP1	RGD	RGD:1359189
Felis catus	CLUAP1	VGNC	VGNC:60987
Mus musculus	CLUAP1	MGD	MGI:1924029
Bos taurus	CLUAP1	VGNC	VGNC:27472
Others	CLUAP1	NCBI