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HUNK - hormonally up-regulated Neu-associated kinase Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 30811

About HUNK

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:31,873,020-32,004,064 (from NCBI)

This gene has 4 transcripts (splice variants), 158 orthologues and 17 paralogues. Broad expression in placenta (RPKM 1.4), colon (RPKM 1.2) and 20 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. [provided by Alliance of Genome Resources, Apr 2022]

HUNK Products (1)

mRNA	Protein	Name
NM_014586.2	NP_055401.1	hormonally up-regulated neu tumor-associated kinase

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	20133759	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HUNK Protein Structure

Pkinase

0
200
400
600
714 a.a.

Protein Preferred Names	Protein Names
hormonally up-regulated neu tumor-associated kinase	B19

HUNK Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	HUNK	P57058	LIMK1	Homo sapiens	P53667	Anti Bait CoIP	20133759
Intra	HUNK	P57058	LIMK1	Homo sapiens	P53667	Y2H Fragment Pooling	35914814

Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases	Alias
Recombinase Activating Gene 1 Deficiency
Immunodeficiency 39	IMD39 Immunodeficiency, Type 39
Combined Cellular And Humoral Immune Defects With Granulomas	Combined Immunodeficiency With Skin Granulomas CCHIDG Cid Due To Rag 1/2 Deficiency Combined Immunodeficiency Due To Rag 1/2 Deficiency Combined Immunodeficiency With Granulomatosis CHIDG Immune Defects, Combined Cellular And Humoral With Granulomas
Immunodeficiency 44	IMD44
Baylisascariasis	Infection By Baylisascaris
Immunodeficiency 31b	IMD31B Immunodeficiency 31b, Mycobacterial And Viral Infections, Autosomal Recessive Autosomal Recessive Stat1 Deficiency Predisposition To Severe Viral Infection Due To Stat1 Deficiency Susceptibility To Viral And Mycobacterial Infections Due To Stat1 Deficiency Stat1 Deficiency, Autosomal Recessive Autosomal Recessive Immunodeficiency 31b, Mycobacterial And Viral Infections Stat1 Deficiency Autosomal Recessive Susceptibility To Mycobacterial And Viral Infections Mycobacterial And Viral Infections Due To Complete Stat1 Deficiency Immunodeficiency, Type 31b, Mycobacterial And Viral Infections, Autosomal Recessive
Cataract 18	Cataract, Autosomal Recessive Congenital 2 Catc2 CTRCT18 Autosomal Recessive Congenital Cataract 2 Cataract 18, Autosomal Recessive Cataract 18 Autosomal Recessive Cataract, Type 18
Cataract 44	CTRCT44 Total Early-Onset Cataract Cataract 44 And Hypotrichosis Cataract And Hypotrichosis Cataract, Type 44

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS06491	HUNK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	HUNK	RGD	RGD:1565091
Bos taurus	HUNK	VGNC	VGNC:49999
Felis catus	HUNK	VGNC	VGNC:62858
Canis familiaris	HUNK	VGNC	VGNC:53027
Mus musculus	HUNK	MGD	MGI:1347352
Macaca mulatta	HUNK	VGNC	VGNC:73386
Others	HUNK	NCBI