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製品番号: HY-162627

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LDHA-IN-6

LDHA-IN-6 (compound 6) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA), with the IC₅₀ of 46 nM. LDHA-IN-6 has antitumor activity.

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CAS 番号: 3043790-18-4
分子式: C₂₃H₂₀F₃N₃O₄
分子量:459.42

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

LDHA-IN-6 構造式

CAS 番号: 3043790-18-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

LDHA-IN-6 (compound 6) is an oral bioactive inhibitor of lactate dehydrogenase-A (LDHA), with the IC₅₀ of 46 nM. LDHA-IN-6 has antitumor activity^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
MIA PaCa-2	IC₅₀	25.552 μM Compound: 6	Antiproliferative activity against human MIA PaCa-2 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis Antiproliferative activity against human MIA PaCa-2 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis	[PMID: 38925013]
PANC-1	IC₅₀	23.944 μM Compound: 6	Antiproliferative activity against human PANC-1 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis Antiproliferative activity against human PANC-1 cells incubated for 48 hrs by Hoechst 33342 and SYTOX green staining based confocal imaging analysis	[PMID: 38925013]

化学情報

CAS 番号 3043790-18-4
分子量 459.42
分子式 C₂₃H₂₀F₃N₃O₄
SMILES

O=C(OC)C(C1=CC=C(C(F)(F)F)C=C1)CC(NC2=CC=C(C(C3=NC=CN3C)=O)C=C2)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Horrick Sharma, et al. Synthesis and biological characterization of an orally bioavailable lactate dehydrogenase-A inhibitor against pancreatic cancer. Eur J Med Chem. 2024 Jun 17:275:116598. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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